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Recently discovered protein domain regulates collagen transport - Mirage News
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar Recently discovered protein domain regulates collagen transport - Mirage News

Recently discovered protein domain regulates collagen transport Mirage News Read here
0 Replies | 104 Views
Tiny Proteins May Play a Key Role in Cancer Spread - Technology Networks
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar Tiny Proteins May Play a Key Role in Cancer Spread - Technology Networks

Tiny Proteins May Play a Key Role in Cancer Spread Technology Networks Read here
0 Replies | 146 Views
3D Protein Structure Analysis Equipment Market Future Prospects ... - The Navajo Post
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar 3D Protein Structure Analysis Equipment Market Future Prospects ... - The Navajo Post

3D Protein Structure Analysis Equipment Market Future Prospects ... The Navajo Post Read here
0 Replies | 144 Views
[NMR paper] Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders
May 22, 2023 - 11:09 PM - by nmrlearner
nmrlearner's Avatar Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders

The intracellular milieu is crowded and heterogeneous, and this can have profound consequences for biomolecule motions and biochemical kinetics. Macromolecular crowding has been traditionally studied in artificial crowders like Ficoll and dextran or globular proteins such as bovine serum albumin. It is, however, not clear if the effects of artificial crowders on such phenomena are the same as the crowding that is experienced in a heterogeneous biological environment. Bacterial cells, for...

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0 Replies | 176 Views
[NMR paper] Metal interactions of ?-synuclein probed by NMR amide-proton exchange
May 22, 2023 - 3:10 AM - by nmrlearner
nmrlearner's Avatar Metal interactions of ?-synuclein probed by NMR amide-proton exchange

The aberrant aggregation of ?-synuclein (?S), a disordered protein primarily expressed in neuronal cells, is strongly associated with the underlying mechanisms of Parkinson's disease. It is now established that ?S has a weak affinity for metal ions and that these interactions alter its conformational properties by generally promoting self-assembly into amyloids. Here, we characterised the nature of the conformational changes associated with metal binding by ?S using nuclear magnetic resonance...

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0 Replies | 126 Views
[NMR paper] Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-?42 aggregation and fibril formation
May 22, 2023 - 3:10 AM - by nmrlearner
nmrlearner's Avatar Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-?42 aggregation and fibril formation

The chaperone Hsp104, a member of the Hsp100/Clp family of translocases, prevents fibril formation of a variety of amyloidogenic peptides in a paradoxically substoichiometric manner. To understand the mechanism whereby Hsp104 inhibits fibril formation, we probed the interaction of Hsp104 with the Alzheimer's amyloid-?42 (A?42) peptide using a variety of biophysical techniques. Hsp104 is highly effective at suppressing the formation of Thioflavin T (ThT) reactive mature fibrils that are readily...

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0 Replies | 124 Views
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