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[ASAP] Active Site Descriptors from 95Mo NMR Signatures of Silica-Supported Mo-Based Olefin Metathesis Catalysts
Jun 01, 2023 - 5:37 PM - by nmrlearner
nmrlearner's Avatar [ASAP] Active Site Descriptors from 95Mo NMR Signatures of Silica-Supported Mo-Based Olefin Metathesis Catalysts

Zachariah J. Berkson, Ran Zhu, Christian Ehinger, Lukas La?tsch, Stefan P. Schmid, Darryl Nater, Stephan Pollitt, Olga V. Safonova, Snędi?s Bjo?rgvinsdo?ttir, Alexander B. Barnes, Yuriy Roma?n-Leshkov, Gregory A. Price, Glenn J. Sunley, and Christophe Cope?ret



Journal of the American Chemical Society
DOI: 10.1021/jacs.3c02201



Source: Journal of the American Chemical Society
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Protein Crystallization Market is expected to reach USD 2.02 Bn. by ... - InvestorsObserver
Jun 01, 2023 - 5:37 PM - by nmrlearner
nmrlearner's Avatar Protein Crystallization Market is expected to reach USD 2.02 Bn. by ... - InvestorsObserver

Protein Crystallization Market is expected to reach USD 2.02 Bn. by ... InvestorsObserver Read here
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Polyproline type II helical antifreeze proteins are widespread in ... - Nature.com
Jun 01, 2023 - 5:37 PM - by nmrlearner
nmrlearner's Avatar Polyproline type II helical antifreeze proteins are widespread in ... - Nature.com

Polyproline type II helical antifreeze proteins are widespread in ... Nature.com Read here
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[NMR paper] Metabolite Analyses Using Nuclear Magnetic Resonance (NMR) Spectroscopy in Plasma of Patients with Prostate Cancer
Jun 01, 2023 - 5:37 PM - by nmrlearner
nmrlearner's Avatar Metabolite Analyses Using Nuclear Magnetic Resonance (NMR) Spectroscopy in Plasma of Patients with Prostate Cancer

Nuclear magnetic resonance (NMR) spectroscopy enables the detection and the quantification of a large range of molecules, including low-molecular-weight metabolites and lipids. NMR spectroscopy is a powerful approach when applied to the high-throughput analysis of plasma or serum samples allowing, in addition, the detection of total proteins, lipoproteins, and signals arising from the glycosylation of circulating acute-phase proteins. Here, we describe the usage of NMR spectroscopy for profiling...

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[NMR paper] Blind assessment of monomeric AlphaFold2 protein structure models with experimental NMR data
Jun 01, 2023 - 5:37 PM - by nmrlearner
nmrlearner's Avatar Blind assessment of monomeric AlphaFold2 protein structure models with experimental NMR data

Recent advances in molecular modeling of protein structures are changing the field of structural biology. AlphaFold-2 (AF2), an AI system developed by DeepMind, Inc., utilizes attention-based deep learning to predict models of protein structures with high accuracy relative to structures determined by X-ray crystallography and cryo-electron microscopy (cryoEM). Comparing AF2 models to structures determined using solution NMR data, both high similarities and distinct differences have been...

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[NMR paper] NMR resonance assignments of 18.5*kDa complex of Arabidopsis thaliana*DRB7.2:DRB4 interaction domains
May 31, 2023 - 7:32 PM - by nmrlearner
nmrlearner's Avatar NMR resonance assignments of 18.5*kDa complex of Arabidopsis thaliana*DRB7.2:DRB4 interaction domains

In higher eukaryotes, the dsRNA binding proteins (dsRBPs) assist the corresponding Dicer in the cleavage of dsRNA precursors to effect post-transcriptional gene regulation through RNA interference. In contrast, the DRB7.2:DRB4 complex in Arabidopsis thaliana acts as a potent inhibitor of Dicer-like 3 (DCL3) processing by sequestering endogenous inverted-repeat dsRNA precursors. DRB7.2 possesses a single dsRNA Binding Domain (dsRBD) flanked by unstructured N- and C-terminal regions. Whereas, DRB4...

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[NMR paper] Analyzing paramagnetic NMR data on target DNA search by proteins using a discrete-state kinetic model for translocation
May 31, 2023 - 7:32 PM - by nmrlearner
nmrlearner's Avatar Analyzing paramagnetic NMR data on target DNA search by proteins using a discrete-state kinetic model for translocation

Before reaching their targets, sequence-specific DNA-binding proteins nonspecifically bind to DNA through electrostatic interactions and stochastically change their locations on DNA. Investigations into the dynamics of DNA-scanning by proteins are nontrivial due to the simultaneous presence of multiple translocation mechanisms and many sites for the protein to nonspecifically bind to DNA. Nuclear magnetic resonance (NMR) spectroscopy can provide information about the target DNA search processes...

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