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» Welcome! Welcome, NMR world! Our visitors map. » Log in User Name Remember Me? Not a member yet? Register Now! Password [NMR paper] Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by (1)H NMR and MS-Based Untargeted Metabolomics Analysis Dec 23, 2024 - 5:21 AM - by nmrlearner Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by (1)H NMR and MS-Based Untargeted Metabolomics Analysis Astragali Radix (AR) is one of the monarch drugs of Fangji Huangqi decoction and has the effects of inducing diuresis to alleviate edema, tonifying and strengthening the body. However, there is a paucity of research regarding the effective fraction and the underlying metabolic mechanism of AR on nephrotic syndrome (NS). This work aims to elucidate the potential mechanisms of AR treating NS, as well as to identify effective part and components. Firstly, body weight, kidney index, 24-h urea... More... 0 Replies | 69 Views [NMR paper] Integrated NMR-crystallography-computational approach for molecular recognition studies of human Galphai3 protein by a small molecule inhibitor Dec 21, 2024 - 10:05 PM - by nmrlearner Integrated NMR-crystallography-computational approach for molecular recognition studies of human Galphai3 protein by a small molecule inhibitor The small molecule IGGi-11 targets G?i subunits of heterotrimeric guanine nucleotide-binding proteins. G? subunits are activated by G-protein-coupled receptors in response to extracellular stimuli by accelerating the exchange of GDP for GTP, but they are also activated by intracellular proteins like GIV, of which elevated levels correlate with increased cell migration and cancer metastasis. IGGi-11 disrupts the interaction of G?i proteins with GIV and inhibits pro-invasive traits of metastatic... More... 0 Replies | 126 Views [NMR paper] A combined NMR and deep neural network approach for enhancing the spectral resolution of aromatic side chains in proteins Dec 20, 2024 - 11:43 PM - by nmrlearner A combined NMR and deep neural network approach for enhancing the spectral resolution of aromatic side chains in proteins Nuclear magnetic resonance (NMR) spectroscopy is an important technique for deriving the dynamics and interactions of macromolecules; however, characterizations of aromatic residues in proteins still pose a challenge. Here, we present a deep neural network (DNN), which transforms NMR spectra recorded on simple uniformly ^(13)C-labeled samples to yield high-quality ¹H-^(13)C correlation maps of aromatic side chains. Key to the success of the DNN is the design of NMR experiments that produce data... More... 0 Replies | 87 Views Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using - ACS Publications Dec 19, 2024 - 9:24 PM - by nmrlearner Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using - ACS Publications Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using ACS Publications Read here 0 Replies | 33 Views [NMR paper] Exploiting (19)F NMR in a Multiplexed Assay for Small GTPase Activity Dec 18, 2024 - 5:51 PM - by nmrlearner Exploiting (19)F NMR in a Multiplexed Assay for Small GTPase Activity Small GTPases (smG) are a 150-member family of proteins, comprising five subfamilies: Ras, Rho, Arf, Rab, and Ran-GTPases. These proteins function as molecular switches, toggling between two distinct nucleotide-bound states. Using traditional multidimensional heteronuclear NMR, even for single smGs, numerous experiments, high protein concentrations, expensive isotope labeling, and long analysis times are necessary. ^(19)F NMR of fluorinated proteins or ligands can overcome these drawbacks. Using... More... 0 Replies | 189 Views [NMR paper] A nitrogen-metabolism inhibitor NmrA regulates conidial production, melanin synthesis and virulence in phytopathogenic fungus Verticillium dahliae Dec 18, 2024 - 5:41 AM - by nmrlearner A nitrogen-metabolism inhibitor NmrA regulates conidial production, melanin synthesis and virulence in phytopathogenic fungus Verticillium dahliae NmrA homologs have been reported as conserved regulators of the nitrogen metabolite repression (NMR) in various fungi. Here, we identified a NmrA homolog in Verticillium dahliae and reported its functions in nitrogen utilization, growth and development, and pathogenesis. VdNmrA interacts with V. dahliae AreA protein and regulates the expression of a typical NCR target, the formamidase gene. VdNmrA deletion mutants exhibited significantly slower colony growth on media with Gln or Arg.... More... 0 Replies | 61 Views [NMR paper] Molecular dynamics as an efficient process to predict (15)N chemical shift anisotropy at very high NMR magnetic fields Dec 18, 2024 - 5:41 AM - by nmrlearner Molecular dynamics as an efficient process to predict (15)N chemical shift anisotropy at very high NMR magnetic fields The emergence of very high NMR magnetic fields will certainly encourage the study of larger biological systems with their dynamics and interactions. NMR spin relaxation allows probing the dynamical properties of proteins where the ^(15)N longitudinal (R(1)) and transverse (R(2)) relaxation rates in addition to the ¹H-^(15)N heteronuclear NOE describe the ps-ns time scale. Their analytical representation involves the chemical shift anisotropy (CSA) effect that represents the major contribution at... More... 0 Replies | 29 Views [NMR paper] Metabolomic Profiling of Tenebrio molitor Reared on Chestnut Shell-Enriched Substrate Using NMR Spectroscopy Dec 17, 2024 - 5:22 PM - by nmrlearner Metabolomic Profiling of Tenebrio molitor Reared on Chestnut Shell-Enriched Substrate Using NMR Spectroscopy The aim of this study was to evaluate the metabolomic profile of T. molitor larvae reared on the following innovative growth substrates: wheat bran (control, CTRL); wheat bran supplemented with 12.5% w/w chestnut shell (TRT1); and wheat bran supplemented with 25% w/w chestnut shell (TRT2) for 14 days of trial. At the end of this experiment, larvae were transformed into insect meals for nutritional characterization. Nuclear Magnetic Resonance (NMR) spectroscopy was carried out to evaluate the... More... 0 Replies | 29 Views Page 1 of 100 1 2 3 11 51 > Last »

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