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Protein Trends & Technologies Market 2023: A Study of the Leading Regions and Players in Industry Forecas - Benzinga
Sep 02, 2023 - 1:54 AM - by nmrlearner
nmrlearner's Avatar Protein Trends & Technologies Market 2023: A Study of the Leading Regions and Players in Industry Forecas Benzinga
Protein Trends & Technologies Market 2023: A Study of the Leading Regions and Players in Industry Forecas - Benzinga
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0 Replies | 207 Views
Structural insights into MIC2 recognition by MIC2-associated protein ... - Nature.com
Sep 02, 2023 - 1:54 AM - by nmrlearner
nmrlearner's Avatar Structural insights into MIC2 recognition by MIC2-associated protein ... - Nature.com

Structural insights into MIC2 recognition by MIC2-associated protein ... Nature.com Read here
0 Replies | 178 Views
[NMR paper] NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750
Sep 02, 2023 - 1:54 AM - by nmrlearner
nmrlearner's Avatar NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750

ZNF750 is a nuclear transcription factor that activates skin differentiation and has tumor suppressor roles in several cancers. Unusually, ZNF750 has only a single zinc-finger (ZNF) domain, Z*, with an amino acid sequence that differs markedly from the CCHH family consensus. Because of its sequence differences Z* is classified as degenerate, presumed to have lost the ability to bind the zinc ion required for folding. AlphaFold predicts an irregular structure for Z* with low confidence. Low...

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0 Replies | 222 Views
Relationship Between Pre- and Post-Operative C-Reactive Protein ... - Cureus
Aug 30, 2023 - 5:24 AM - by nmrlearner
nmrlearner's Avatar Relationship Between Pre- and Post-Operative C-Reactive Protein ... - Cureus

Relationship Between Pre- and Post-Operative C-Reactive Protein ... Cureus Read here
0 Replies | 196 Views
Everything you need to know about ‘protein-folding problem’ – but were too afraid to ask - Newslaundry
Aug 28, 2023 - 8:28 AM - by nmrlearner
nmrlearner's Avatar Everything you need to know about ‘protein-folding problem’ – but were too afraid to ask Newslaundry
Everything you need to know about ‘protein-folding problem’ – but were too afraid to ask - Newslaundry
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0 Replies | 212 Views
[NMR paper] Studies of proline conformational dynamics in IDPs by 13C-detected cross-correlated NMR relaxation
Aug 28, 2023 - 8:28 AM - by nmrlearner
nmrlearner's Avatar Studies of proline conformational dynamics in IDPs by 13C-detected cross-correlated NMR relaxation

Intrinsically disordered proteins (IDPs) are significantly enriched in proline residues, which can populate specific local secondary structural elements called PPII helices, characterized by small packing densities. Proline is often thought to promote disorder, but it can participate in specific ?·CH interactions with aromatic side chains resulting in reduced conformational flexibilities of the polypeptide. Differential local motional dynamics are relevant for the stabilization of preformed...

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0 Replies | 559 Views
[NMR paper] Unique epitope-antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display
Aug 26, 2023 - 9:35 PM - by nmrlearner
nmrlearner's Avatar Unique epitope-antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display

Carbonic anhydrase (CA)-IX is an extracellular enzyme that is essential in the adaptation of tumor cells to their increasingly more hypoxic and acidic microenvironment. Within the family of carbonic anhydrases, CA-IX is unique in that it is the only CA with an N-terminal intrinsically disordered region (IDR) containing a proteoglycan (PG)-like domain. This PG-like IDR has been described to be instrumental in CA-IX's enzyme activity, as well as tumor cell motility and invasion. We have...

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0 Replies | 200 Views
[NMR paper] Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR
Aug 26, 2023 - 9:35 PM - by nmrlearner
nmrlearner's Avatar Binding Affinity Studies of Nicotinamide N-methyltransferase and Ligands by Saturation Transfer Difference NMR

CONCLUSION: The binding affinity of nicotinamide and SAH to NNMT and its mutants were obtained by STD NMR in this study. It was found that nicotinamide and SAH bind to WT in a particular orientation, and Y20 is critical for their binding orientation and affinity to NNMT.

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0 Replies | 215 Views
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