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Kanazawa University research: High-speed atomic force microscopy takes on intrinsically disordered proteins - Yahoo Finance
Dec 04, 2020 - 3:46 PM - by nmrlearner
nmrlearner's Avatar Kanazawa University research: High-speed atomic force microscopy takes on intrinsically disordered proteins - Yahoo Finance

Kanazawa University research: High-speed atomic force microscopy takes on intrinsically disordered proteins Yahoo Finance Read here
0 Replies | 37 Views
'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures - Nature.com
Dec 03, 2020 - 9:00 AM - by nmrlearner
nmrlearner's Avatar 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures Nature.com
'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures - Nature.com
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0 Replies | 35 Views
Protein Trends & Technologies Market: Global Analysis Of Key Manufacturers, Dynamics & Forecast 2020-2026 - The Market Feed
Dec 03, 2020 - 9:00 AM - by nmrlearner
nmrlearner's Avatar Protein Trends & Technologies Market: Global Analysis Of Key Manufacturers, Dynamics & Forecast 2020-2026 The Market Feed
Protein Trends & Technologies Market: Global Analysis Of Key Manufacturers, Dynamics & Forecast 2020-2026 - The Market Feed
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0 Replies | 34 Views
[NMR paper] The Potential of 19F NMR Application in GPCR Biased Drug Discovery.
Dec 01, 2020 - 11:49 PM - by nmrlearner
nmrlearner's Avatar The Potential of 19F NMR Application in GPCR Biased Drug Discovery.

Related Articles The Potential of 19F NMR Application in GPCR Biased Drug Discovery.

Trends Pharmacol Sci. 2020 Nov 26;:

Authors: Wang X, McFarland A, Madsen JJ, Aalo E, Ye L

Abstract
Although structure-based virtual drug discovery is revolutionizing the conventional high-throughput cell-based screening system, its limitation is obvious, together with other critical challenges. In particular, the resolved static snapshots fail to represent a full free-energy landscape due to homogenization in structural determination processing. The loss of conformational heterogeneity and related functional diversity emphasize the necessity of developing an approach that can fill this space. In this regard, NMR holds undeniable potential. However, outstanding questions regarding the NMR application remain. This review summarizes the limitations of current drug discovery and explores the potential of 19F NMR in establishing a conformation-guided drug screening system, advancing... [Read More]
0 Replies | 54 Views
[NMR paper] Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy.
Dec 01, 2020 - 11:49 PM - by nmrlearner
nmrlearner's Avatar Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy.

Related Articles Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy.

J Pharm Sci. 2020 Nov 26;:

Authors: Li M, Koranne S, Fang R, Lu X, Williams DM, Munson EJ, Bhambhani A, Su Y

Abstract
Biophysical and biochemical instability of therapeutic proteins in the solution state may necessitate the development of products in the solid form, due to their enhanced stability. Lyophilization is a widely used method to ensure dry state stabilization of biological products. A commonly encountered issue is the pH shifts that can occur due to undesired crystallization of a buffer component, resulting in loss of protein activities. However, it is technically challenging to noninvasively investigate the physicochemical environment in the lyophile matrix. In this work, we demonstrate an approach based on solid-state NMR to investigate the microenvironmental... [Read More]
0 Replies | 32 Views
[NMR paper] Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples.
Dec 01, 2020 - 11:49 PM - by nmrlearner
nmrlearner's Avatar Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples.

Related Articles Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples.

J Proteome Res. 2020 11 06;19(11):4428-4441

Authors: Loo RL, Lodge S, Kimhofer T, Bong SH, Begum S, Whiley L, Gray N, Lindon JC, Nitschke P, Lawler NG, Schäfer H, Spraul M, Richards T, Nicholson JK, Holmes E

Abstract
Quantitative nuclear magnetic... [Read More]
0 Replies | 29 Views
[NMR paper] NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.
Dec 01, 2020 - 11:49 PM - by nmrlearner
nmrlearner's Avatar NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.

Related Articles NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA.

Sci Rep. 2020 05 12;10(1):7896

Authors: Sewell L, Stylianou F, Xu Y, Taylor J, Sefer L, Matthews S

Abstract
The biofilms of Enterobacteriaceae are fortified by assembly of curli amyloid fibres on the cell surface. Curli not only provides structural reinforcement, but also facilitates surface adhesion. To prevent toxic intracellular accumulation of amyloid precipitate, secretion of the major curli subunit, CsgA, is tightly regulated. In this work, we have employed solution state NMR spectroscopy to characterise... [Read More]
0 Replies | 32 Views
[NMR paper] Contemporary Approaches for Site-selective Dual Functionalization of Proteins
Dec 01, 2020 - 11:49 PM - by nmrlearner
nmrlearner's Avatar Contemporary Approaches for Site-selective Dual Functionalization of Proteins


Angewandte Chemie International Edition, Accepted Article.

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0 Replies | 27 Views
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