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Evolution and folding of repeat proteins - pnas.org
Jul 30, 2022 - 7:25 AM - by nmrlearner
nmrlearner's Avatar Evolution and folding of repeat proteins - pnas.org

Evolution and folding of repeat proteins pnas.org Read here
0 Replies | 16 Views
[NMR paper] NOAH-(15N/13C)-CEST NMR supersequence for dynamics studies of biomolecules
Jul 29, 2022 - 12:46 PM - by nmrlearner
nmrlearner's Avatar NOAH-(15N/13C)-CEST NMR supersequence for dynamics studies of biomolecules

An NMR supersequence is introduced for the rapid acquisition of ^(15)N-CEST and methyl-^(13)C-CEST experiments in the same pulse sequence for applications to proteins. The high sensitivity and accuracy allows the simultaneous quantitative characterization of backbone and side-chain dynamics on the millisecond timescale ideal for routine screening for alternative protein states.

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0 Replies | 46 Views
[NMR paper] Core packing of well-defined X-ray and NMR structures is the same
Jul 28, 2022 - 9:53 PM - by nmrlearner
nmrlearner's Avatar Core packing of well-defined X-ray and NMR structures is the same

Numerous studies have investigated the differences and similarities between protein structures determined by solution NMR spectroscopy and those determined by X-ray crystallography. A fundamental question is whether any observed differences are due to differing methodologies or to differences in the behavior of proteins in solution versus in the crystalline state. Here, we compare the properties of the hydrophobic cores of high-resolution protein crystal structures and those in NMR structures,...

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0 Replies | 38 Views
[NMR paper] O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations
Jul 28, 2022 - 9:53 PM - by nmrlearner
nmrlearner's Avatar O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations

Anti-mucin1 (MUC1) antibodies have been widely used for breast cancer diagnosis and treatment. This is based on the fact that MUC1 undergoes aberrant glycosylation upon cancer progression, and anti-MUC1 antibodies differentiate changes in glycan structure. MY.1E12 is a promising anti-MUC1 antibody with a distinct specificity toward MUC1 modified with an immature O-glycan (NeuAc?(2-3)Gal?(1-3)GalNAc) on a specific Thr. However, the structural basis for the interaction between MY.1E12 and MUC1...

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0 Replies | 33 Views
Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins | Proceedings of the National Academy of Sciences - pnas.org
Jul 28, 2022 - 8:34 AM - by nmrlearner
nmrlearner's Avatar Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins | Proceedings of the National Academy of Sciences - pnas.org

Bioinspired stretchable molecular composites of 2D-layered materials and tandem repeat proteins | Proceedings of the National Academy of Sciences pnas.org Read here
0 Replies | 26 Views
[NMR paper] Probing the Interactions of Splicing Regulatory Small Molecules and Proteins with U1 snRNP Using NMR Spectroscopy
Jul 28, 2022 - 8:34 AM - by nmrlearner
nmrlearner's Avatar Probing the Interactions of Splicing Regulatory Small Molecules and Proteins with U1 snRNP Using NMR Spectroscopy

Alternative RNA splicing is an essential part of gene expression that not only increases the protein diversity of metazoan but also provides an additional layer of gene expression regulation. The U1 small ribonucleoparticle (U1 snRNP) plays an essential role in seeding spliceosome assembly and its binding on weak 5'-splice sites is regulated by transient interactions with splicing factors. Recent progress in allele specific splicing correction has shown the therapeutic potential offered by small...

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0 Replies | 38 Views
[NMR paper] NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering
Jul 28, 2022 - 8:34 AM - by nmrlearner
nmrlearner's Avatar NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering

The SARS-CoV-2 nucleocapsid (N) protein is crucial for the highly organized packaging and transcription of the genomic RNA. Studying atomic details of the role of its intrinsically disordered regions (IDRs) in RNA recognition is challenging due to the absence of structure and to the repetitive nature of their primary sequence. IDRs are known to act in concert with the folded domains of N and here we use NMR spectroscopy to identify the priming events of N interacting with a regulatory SARS-CoV-2...

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0 Replies | 36 Views
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