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Comparative analysis of 13 C chemical shifts of β-sheet amyloid proteins and outer membrane proteins
Apr 13, 2021 - 12:50 AM - by nmrlearner
nmrlearner's Avatar Comparative analysis of 13 C chemical shifts of β-sheet amyloid proteins and outer membrane proteins

Abstract

Cross-β amyloid fibrils and membrane-bound β-barrels are two important classes of β-sheet proteins. To investigate whether there are systematic differences in the backbone and sidechain conformations of these two families of proteins, here we analyze the 13C chemical shifts of 17 amyloid proteins and 7 β-barrel membrane proteins whose high-resolution structures have been determined by NMR. These 24 proteins contain 373 β-sheet residues in amyloid fibrils and 521 β-sheet residues in β-barrel membrane proteins. The 13C chemical shifts are shown in 2D 13C??13C correlation maps, and the amino acid residues are categorized by two criteria: (1) whether they occur in β-strand segments or in loops and turns; (2) whether they are water-exposed or dry, facing other residues or lipids. We also examine the abundance of each amino acid in amyloid proteins and β-barrels and compare the sidechain rotameric populations. The 13C chemical shifts indicate that hydrophobic methyl-rich residues and aromatic residues exhibit larger static sidechain conformational disorder in amyloid fibrils than in β-barrels. In comparison, hydroxyl- and amide-containing polar residues have more ordered sidechains and more ordered backbones in amyloid fibrils than in β-barrels. These trends can be explained by steric zipper interactions between β-sheet planes in cross-β fibrils, and by the interactions of β-barrel residues with lipid and water in the membrane. These conformational trends should be useful for structural analysis of amyloid fibrils and β-barrels based principally on NMR chemical shifts.

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Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data - GlobeNewswire
Apr 13, 2021 - 12:50 AM - by nmrlearner
nmrlearner's Avatar Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data - GlobeNewswire

Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data GlobeNewswire Read here
0 Replies | 9 Views
Protein Trends & Technologies Market 2021 Thriving at a Tremendous Growth SoccerNurds - SoccerNurds
Apr 13, 2021 - 12:50 AM - by nmrlearner
nmrlearner's Avatar Protein Trends & Technologies Market 2021 Thriving at a Tremendous Growth SoccerNurds SoccerNurds
Protein Trends & Technologies Market 2021 Thriving at a Tremendous Growth SoccerNurds - SoccerNurds
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0 Replies | 8 Views
Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data - GlobeNewswire
Apr 12, 2021 - 12:40 PM - by nmrlearner
nmrlearner's Avatar Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data - GlobeNewswire

Protein Crystallization & Crystallography Market Size to Reach USD 2.23 Billion By 2028: CAGR of 9.2% | Reports And Data GlobeNewswire Read here
0 Replies | 11 Views
Deep dive into key COVID-19 protein is a step toward new drugs, vaccines - Phys.org
Apr 10, 2021 - 7:31 PM - by nmrlearner
nmrlearner's Avatar Deep dive into key COVID-19 protein is a step toward new drugs, vaccines Phys.org
Deep dive into key COVID-19 protein is a step toward new drugs, vaccines - Phys.org
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0 Replies | 10 Views
Global Protein Crystallization & Crystallography Market Analysis on Factors Influencing 2021 Industry Trends - openPR
Apr 10, 2021 - 3:40 AM - by nmrlearner
nmrlearner's Avatar Global Protein Crystallization & Crystallography Market Analysis on Factors Influencing 2021 Industry Trends - openPR

Global Protein Crystallization & Crystallography Market Analysis on Factors Influencing 2021 Industry Trends openPR Read here
0 Replies | 13 Views
Study reveals evolutionary origins of fold-switching protein | National Academy of Sciences - pnas.org
Apr 10, 2021 - 3:40 AM - by nmrlearner
nmrlearner's Avatar Study reveals evolutionary origins of fold-switching protein | National Academy of Sciences - pnas.org

Study reveals evolutionary origins of fold-switching protein | National Academy of Sciences pnas.org Read here
0 Replies | 11 Views
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