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The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis | Scientific Data - Nature.com
Mar 06, 2024 - 5:09 AM - by nmrlearner
nmrlearner's Avatar The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis | Scientific Data - Nature.com

The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis | Scientific Data Nature.com Read here
0 Replies | 84 Views
Pea aphid odorant-binding protein ApisOBP6 discriminates between aphid sex pheromone components, aphid alarm ... - ScienceDirect.com
Mar 04, 2024 - 10:56 PM - by nmrlearner
nmrlearner's Avatar Pea aphid odorant-binding protein ApisOBP6 discriminates between aphid sex pheromone components, aphid alarm ... - ScienceDirect.com

Pea aphid odorant-binding protein ApisOBP6 discriminates between aphid sex pheromone components, aphid alarm ... ScienceDirect.com Read here
0 Replies | 79 Views
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite - ScienceDirect.com
Mar 04, 2024 - 12:34 AM - by nmrlearner
nmrlearner's Avatar Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite - ScienceDirect.com

Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite ScienceDirect.com Read here
0 Replies | 87 Views
[NMR paper] 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson's disease
Mar 03, 2024 - 3:50 AM - by nmrlearner
nmrlearner's Avatar 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson's disease

CONCLUSION: BSHXHZF combined with BMSCs can inhibit liver fibrosis and hepatocyte apoptosis by improving related metabolic disorders, and achieving therapeutic effects in WD-related liver fibrosis.

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0 Replies | 324 Views
[NMR paper] NMR tools to detect protein allostery
Mar 02, 2024 - 3:40 PM - by nmrlearner
nmrlearner's Avatar NMR tools to detect protein allostery

Allostery is a fundamental mechanism of cellular homeostasis by intra-protein communication between distinct functional sites. It is an internal process of proteins to steer interactions not only with each other but also with other biomolecules such as ligands, lipids, and nucleic acids. In addition, allosteric regulation is particularly important in enzymatic activities. A major challenge in structural and molecular biology today is unraveling allosteric sites in proteins, to elucidate the...

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0 Replies | 82 Views
[NMR paper] A Novel NMR-Based Protocol to Screen Ultralow Molecular Weight Fragments
Mar 01, 2024 - 10:10 PM - by nmrlearner
nmrlearner's Avatar A Novel NMR-Based Protocol to Screen Ultralow Molecular Weight Fragments

Fragment-based lead discovery has emerged as one of the most efficient screening strategies for finding hit molecules in drug discovery. Recently, a novel strategy based on a class of fragments characterized by an ultralow molecular weight (ULMW) has been proposed. These fragments bind to the target with a very low affinity, requiring reliable biophysical methods for detection. The most notable application of ULMW used a set of 81 fragments, named MiniFrags, and screened them by X-ray...

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0 Replies | 65 Views
[NMR paper] Progress, Challenges and Opportunities of NMR and XL-MS for Cellular Structural Biology
Mar 01, 2024 - 10:10 PM - by nmrlearner
nmrlearner's Avatar Progress, Challenges and Opportunities of NMR and XL-MS for Cellular Structural Biology

The validity of protein structures and interactions, whether determined under ideal laboratory conditions or predicted by AI tools such as Alphafold2, to precisely reflect those found in living cells remains to be examined. Moreover, understanding the changes in protein structures and interactions in response to stimuli within living cells, under both normal and disease conditions, is key to grasping proteins' functionality and cellular processes. Nevertheless, achieving high-resolution...

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0 Replies | 82 Views
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