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» Welcome! Welcome, NMR world! Our visitors map. » Log in User Name Remember Me? Not a member yet? Register Now! Password Scientists Probe Druggability of Covid Nucleocapsid Protein RNA ... - Mirage News Apr 03, 2023 - 12:58 PM - by nmrlearner Scientists Probe Druggability of Covid Nucleocapsid Protein RNA ... - Mirage News Scientists Probe Druggability of Covid Nucleocapsid Protein RNA ... Mirage News Read here 0 Replies | 260 Views Protein Characterization and Identification Market Growing at a CAGR of 14.0% by 2030 | Thermo Fisher Scientif - openPR Apr 03, 2023 - 12:58 PM - by nmrlearner Protein Characterization and Identification Market Growing at a CAGR of 14.0% by 2030 | Thermo Fisher Scientif - openPR Protein Characterization and Identification Market Growing at a CAGR of 14.0% by 2030 | Thermo Fisher Scientif openPR Read here 0 Replies | 251 Views [NMR paper] Site-specific protein backbone deuterium 2H? quadrupolar patterns by proton-detected quadruple-resonance 3D 2H?c?NH MAS NMR spectroscopy Mar 31, 2023 - 9:21 AM - by nmrlearner Site-specific protein backbone deuterium 2H? quadrupolar patterns by proton-detected quadruple-resonance 3D 2H?c?NH MAS NMR spectroscopy A novel deuterium-excited and proton-detected quadruple-resonance three-dimensional (3D) ²H(?)c(?)NH MAS nuclear magnetic resonance (NMR) method is presented to obtain site-specific ²H(?) deuterium quadrupolar couplings from protein backbone, as an extension to the 2D version of the experiment reported earlier. Proton-detection results in high sensitivity compared to the heteronuclei detection methods. Utilizing four independent radiofrequency (RF) channels (quadruple-resonance), we managed to... More... 0 Replies | 463 Views [NMR paper] Structure Determination of Challenging Protein-Peptide Complexes Combining NMR Chemical Shift Data and Molecular Dynamics Simulations Mar 31, 2023 - 9:21 AM - by nmrlearner Structure Determination of Challenging Protein-Peptide Complexes Combining NMR Chemical Shift Data and Molecular Dynamics Simulations Intrinsically disordered regions of proteins often mediate important protein-protein interactions. However, the folding-upon-binding nature of many polypeptide-protein interactions limits the ability of modeling tools to predict the three-dimensional structures of such complexes. To address this problem, we have taken a tandem approach combining NMR chemical shift data and molecular simulations to determine the structures of peptide-protein complexes. Here, we use the MELD (Modeling Employing... More... 0 Replies | 228 Views [NMR paper] A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations Mar 31, 2023 - 9:21 AM - by nmrlearner A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations Central metabolism has a profound impact on the clinical phenotypes and penetrance of neurological diseases such as Alzheimer's (AD) and Parkinson's (PD) diseases, Amyotrophic Lateral Sclerosis (ALS) and Autism Spectrum Disorder (ASD). In contrast to the multifactorial origin of these neurological diseases, neurodevelopmental impairment and neurodegeneration in Familial Dysautonomia (FD) results from a single point mutation in the ELP1 gene. FD patients represent a well-defined population who... More... 0 Replies | 242 Views [NMR paper] A Comparison of Bonded and Nonbonded Zinc(II) Force Fields with NMR Data Mar 31, 2023 - 9:21 AM - by nmrlearner A Comparison of Bonded and Nonbonded Zinc(II) Force Fields with NMR Data Classical molecular dynamics (MD) simulations are widely used to inspect the behavior of zinc(II)-proteins at the atomic level, hence the need to properly model the zinc(II) ion and the interaction with its ligands. Different approaches have been developed to represent zinc(II) sites, with the bonded and nonbonded models being the most used. In the present work, we tested the well-known zinc AMBER force field (ZAFF) and a recently developed nonbonded force field (NBFF) to assess how accurately... More... 0 Replies | 249 Views [NMR paper] Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications Mar 31, 2023 - 9:21 AM - by nmrlearner Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications The Notch signaling pathway, an important cell fate determination pathway, is modulated by the ubiquitin ligase Deltex. Here, we investigate the structural basis for Deltex-Notch interaction. We used nuclear magnetic resonance (NMR) spectroscopy to assign the backbone of the Drosophila Deltex WWE(2) domain and mapped the binding site of the Notch ankyrin (ANK) domain to the N-terminal WWE(A) motif. Using cultured Drosophila S2R+ cells, we find that point substitutions within the ANK-binding... More... 0 Replies | 260 Views [NMR paper] Accurate Determination of Motional Amplitudes in Biomolecules by Solid-State NMR Mar 28, 2023 - 8:32 AM - by nmrlearner Accurate Determination of Motional Amplitudes in Biomolecules by Solid-State NMR Protein dynamics are an intrinsically important factor when considering a protein's biological function. Understanding these motions is often limited through the use of static structure determination methods, namely, X-ray crystallography and cryo-EM. Molecular simulations have allowed for the prediction of global and local motions of proteins from these static structures. Nevertheless, determining local dynamics at residue-specific resolution through direct measurement remains crucial.... More... 0 Replies | 237 Views Page 100 of 100 « First < 50 90 98 99 100

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