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Highly Stable Magic Angle Spinning Spherical Rotors Lacking Turbine Grooves
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

Highly Stable Magic Angle Spinning Spherical Rotors Lacking Turbine Grooves

Osborn Popp, Thomas M., Alexander Däpp, Chukun Gao, Pin-Hui Chen, Lauren E. Price, Nicholas H. Alaniva, and Alexander B. Barnes. “Highly Stable Magic Angle Spinning Spherical Rotors Lacking Turbine Grooves.” Preprint. Solid-state NMR/Instrumentation, April 1, 2020.


https://doi.org/10.5194/mr-2020-2.


The use of spherical rotors for magic angle spinning offers a number of advantages including improved sample exchange, efficient microwave coupling for dynamic nuclear polarization nuclear magnetic resonance (NMR) experiments and, most significantly, high frequency and stable spinning with minimal risk of rotor crash. Here we demonstrate the simple retrofitting of a commercial NMR probe with MAS spheres for solid-state NMR. We analyze a series of turbine groove 5 geometries to investigate the importance of the rotor surface on spinning performance. Of note, rotors lacking any surface modification spin rapidly and stably even without feedback control. The high stability of a spherical rotor about the magic angle is shown to be dependent on its inertia tensor rather than the presence of turbine grooves.





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Postdoc position available at Takeda
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

Postdoc position available at Takeda



Please pass this job notice (link below) on to anyone you think may be interested. There is an exciting industrial Postdoc position available at Takeda Pharmaceuticals in Cambridge. It’s main focus is to apply low and high field NMR spectrometry as a Process Analytical Technology (PAT). It’s also a great way to get industry experience!


https://shire.wd5.myworkdayjobs.com/...ent_R0049378-2






Thanks
Mark


Mark J. Milton PhD
Associate Fellow
Takeda Pharmaceuticals Inc
35 Landsdowne St.
Cambridge, MA
02139


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0 Replies | 53 Views
[NMR] 2nd PhD Position in Dissolution DNP at the University of Vienna #DNPNMR
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

[NMR] 2nd PhD Position in Dissolution DNP at the University of Vienna #DNPNMR

Dear colleagues,


a 2nd 4-year Ph.D. position at the institute of biological chemistry at the University of Vienna is available in the field of dissolution DNP with a special focus on biomineralization.


A project starts the 01.10.20 and a description can be found below. I would like to invite interested students to send an application including a letter of motivation (German or English) directly to:
dennis.kurzbach@univie.ac.at.


With kind regards,
Dennis Kurzbach


Project Description:
The DNP group of the University Vienna (www.Vienna-DNP.at) is looking for a motivated student to carry out a PhD thesis project centered around novel (hyperpolarization) tools based on NMR spectroscopy for the characterization of biomineralization processes.


Our lab is working on combining dissolution dynamic nuclear polarization
(DDNP) [1], a technique to improve signal intensities in NMR spectra, with time-resolved detection of biomolecular NMR spectra on milliseconds to minutes time-scales. Our lab is equipped with 8 state-of-the-art NMR devices and integrated into a fully equipped biochemistry facility.


The project is centered around the understanding of biomineralization processes, i.e. the ability of living organisms to produce solid phases. It aims at the development of time-resolved models that describe the peptides' mineralization events at an atomistic level... [Read More]
0 Replies | 54 Views
[NMR] Dr. Ieva Goldberga | 10th DNP/NMR Educational Tutorial on July 10
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

[NMR] Dr. Ieva Goldberga | 10th DNP/NMR Educational Tutorial on July 10

Dear NMR Enthusiast,


The 10th Educational Tutorial will be given by Dr. Ieva Goldberga, a postdoc in Prof. Danielle Laurencin's lab at University of Montpellier on the topic:


"Relaxation-assisted spectral editing in solid-state NMR spectroscopy of biological materials”.


Abstract:
Relaxation analysis in heterogeneous systems can be complicated due to overlapping resonances. In this tutorial, we will consider the use of the inverse Laplace transform to process biexponential relaxation decays to extract information from complex unresolved spectra. The first part will cover ILT and its use in NMR spectroscopy; the second part will consider this methodology in biological materials: collagen and bone.


Speaker's biography:


2015: MChem, University of Southampton (Dr. Marina Carravetta)
2020: PhD Chemistry, University of Cambridge (Prof. Melinda J. Duer)
2019- present: Postdoc at University of Montpellier (Dr. Danielle Laurencin)


Here are the webinar details:
Time: Friday, July 10, 2020, 08:30 AM California or 5:30 PM Paris or 9:00 PM Delhi
Join Meeting: https://ucsb.zoom.us/j/92480496788
Meeting ID: 924 8049 6788


Best regards,
Global NMR Discussion Meetings


PS. We are glad that you are liking our tutorials. In case you missed it or want to hear it again, here is the link to our previous sessions:
... [Read More]
0 Replies | 50 Views
Nitroxide Derivatives for Dynamic Nuclear Polarization in Liquids: The Role of Rotational Diffusion #DNPNMR
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

Nitroxide Derivatives for Dynamic Nuclear Polarization in Liquids: The Role of Rotational Diffusion #DNPNMR

Levien, M., M. Hiller, I. Tkach, M. Bennati, and T. Orlando. “Nitroxide Derivatives for Dynamic Nuclear Polarization in Liquids: The Role of Rotational Diffusion.” The Journal of Physical Chemistry Letters 11, no. 5 (March 5, 2020): 1629–35.
https://doi.org/10.1021/acs.jpclett.0c00270.


Polarization transfer efficiency in liquid-state dynamic nuclear polarization (DNP) depends on the interaction between polarizing agents (PAs) and target nuclei modulated by molecular motions. We show how translational and rotational diffusion differently affect the DNP efficiency. These contributions were disentangled by measuring 1HDNP enhancements of toluene and chloroform doped with nitroxide derivatives at 0.34 T as a function of either the temperature or the size of the PA. The results were employed to analyze 13C-DNP data at higher fields, where the polarization transfer is also driven by the Fermi contact interaction. In this case, bulky nitroxide PAs perform better than the small TEMPONE radical due to structural fluctuations of the ring conformation. These findings will help in designing PAs with features specifically optimized for liquid-state DNP at various magnetic fields.






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DNP and Cellular Solid-state NMR #DNPNMR
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

DNP and Cellular Solid-state NMR #DNPNMR

Paioni, Alessandra Lucini, Marie A M Renault, and Marc Baldus. “DNP and Cellular Solid-State NMR,” 7:12, 2018.

https://onlinelibrary.wiley.com/doi/...590.emrstm1561.
Solid-state nuclear magnetic resonance (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity. Revolutionary developments in the field of dynamic nuclear polarization (DNP) have greatly enhanced ssNMR sensitivity. In this article, we discuss ssNMR concepts and applications that make use of these advancements and enable the study of complex biomolecular and even cellular systems at unprecedented structural resolution and molecular detail.



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0 Replies | 51 Views
The surface chemistry of a nanocellulose drug carrier unravelled by MAS-DNP #DNPNMR
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

The surface chemistry of a nanocellulose drug carrier unravelled by MAS-DNP #DNPNMR

Kumar, Akshay, Hippolyte Durand, Elisa Zeno, Cyril Balsollier, Bastien Watbled, Cecile Sillard, Sébastien Fort, et al. “The Surface Chemistry of a Nanocellulose Drug Carrier Unravelled by MAS-DNP.” Chemical Science, 2020, 10.1039.C9SC06312A.


https://doi.org/10.1039/C9SC06312A.


Cellulose nanofibrils (CNF) are renewable bio-based materials with high specific area, which makes them ideal candidates for multiple emerging applications including for instance on-demand drug release. However, in-depth chemical and structural characterization of the CNF surface chemistry is still an open challenge, especially for low weight percentage of functionalization. This currently prevents the development of efficient, cost-effective and reproducible green synthetic routes and thus the widespread development of targeted and responsive drug-delivery CNF carriers. We show in this work how we use dynamic nuclear polarization (DNP) to overcome the sensitivity limitation of conventional solid-state NMR and gain insight into the surface chemistry of drug-functionalized TEMPO-oxidized cellulose nanofibrils. The DNP enhanced-NMR data can report unambiguously on the presence of trace amounts of TEMPO moieties and depolymerized cellulosic units in the starting material, as well as coupling agents on the CNFs surface (used in the heterogeneous reaction). This enables a precise estimation of the drug loading while differentiating adsorption from covalent bonding (~1 wt% in our case) as opposed to other analytical... [Read More]
0 Replies | 60 Views
[NMR] Permanent position for a researcher - staff scientist at CEA Grenoble in DNP-enhanced solid-state NMR #DNPNMR
Aug 07, 2020 - 8:10 PM - by nmrlearner
nmrlearner's Avatar From The DNP-NMR Blog:

[NMR] Permanent position for a researcher - staff scientist at CEA Grenoble in DNP-enhanced solid-state NMR #DNPNMR






Permanent position opening for a researcher - staff scientist at CEA Grenoble In the field of DNP-enhanced solid-state NMR




Job description


The Interdisciplinary Research Institute of Grenoble (IRIG) has an open position for a researcher - staff scientist specialist in NMR spectroscopy applied to the chemical sciences. The successful candidate will be affiliated to the Modeling and Exploration of Materials Laboratory (MEM), a joint research unit of CEA and the University Grenoble Alpes. He/she will join the DNP research group led by G. De Paëpe at the IRIG, CEA Grenoble, France.


The successful candidate will participate in the research activities of the group, will build and manage new projects with academic and industrial partners. He/She will also be in charge of the DNP-NMR lab equipment in terms of day-to-day operation, maintenance, hardware troubleshooting and fixing. As such, duties include operation of 2 high-field DNP-NMR spectrometers, a fully automated cryostat for close-loop cryogenic helium sample spinning, developing and testing helium/nitrogen fast MAS DNP probes. A central aspect of the work will consist in setting up established pulse sequences (for spin ½ and quadrupolar nuclei) but also to design and develop innovative sequences, data acquisition and processing protocols, as well as user-friendly post-processing analysis tools. The position implies as well, taking an active part in training and guiding graduate students from the group.

... [Read More]
0 Replies | 57 Views
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