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Chemical shift transfer: an effective strategy for protein NMR assignment with ARTINA - Frontiers
Sep 08, 2024 - 2:40 AM - by nmrlearner
nmrlearner's Avatar Chemical shift transfer: an effective strategy for protein NMR assignment with ARTINA - Frontiers

Chemical shift transfer: an effective strategy for protein NMR assignment with ARTINA Frontiers Read here
0 Replies | 98 Views
NMR structures of two designed proteins with high sequence identity but different fold and function - pnas.org
Sep 07, 2024 - 2:30 PM - by nmrlearner
nmrlearner's Avatar NMR structures of two designed proteins with high sequence identity but different fold and function - pnas.org

NMR structures of two designed proteins with high sequence identity but different fold and function pnas.org Read here
0 Replies | 95 Views
Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy - pnas.org
Sep 06, 2024 - 12:19 PM - by nmrlearner
nmrlearner's Avatar Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy - pnas.org

Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy pnas.org Read here
0 Replies | 207 Views
Equilibrium NMR studies of unfolded and partially folded proteins - Nature.com
Sep 04, 2024 - 8:59 AM - by nmrlearner
nmrlearner's Avatar Equilibrium NMR studies of unfolded and partially folded proteins - Nature.com

Equilibrium NMR studies of unfolded and partially folded proteins Nature.com Read here
0 Replies | 108 Views
The molecular basis for protein kinase A anchoring revealed by solution NMR - Nature.com
Sep 03, 2024 - 5:00 AM - by nmrlearner
nmrlearner's Avatar The molecular basis for protein kinase A anchoring revealed by solution NMR - Nature.com

The molecular basis for protein kinase A anchoring revealed by solution NMR Nature.com Read here
0 Replies | 104 Views
[NMR paper] Lysine methylation: A strategy to improve in-cell NMR spectroscopy of proteins
Sep 02, 2024 - 2:55 PM - by nmrlearner
nmrlearner's Avatar Lysine methylation: A strategy to improve in-cell NMR spectroscopy of proteins

BACKGROUND: In-cell NMR is a valuable technique for investigating protein structure and function in cellular environments. However, challenges arise due to highly crowded cellular environment, where nonspecific interactions between the target protein and other cellular components can lead to signals broadening or disappearance in NMR spectra.

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0 Replies | 758 Views
[NMR paper] Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin
Sep 02, 2024 - 2:54 AM - by nmrlearner
nmrlearner's Avatar Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin

Sorcin is a penta-EF hand calcium-binding protein that confers multidrug resistance in cancer cells. It regulates cellular Ca^(2+) homeostasis by interacting with calcium channels such as Ryanodine receptor 2 and Sarcoplasmic/endoplasmic reticulum Ca^(2+)-ATPase in a calcium-dependent manner. The crystal structure of the Sorcin has been determined in both calcium-free and calcium-bound states to understand calcium-binding induced conformational change. However, due to its flexibility, most of...

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0 Replies | 118 Views
[NMR paper] Solution NMR backbone assignment of the N-terminal tandem Zalpha1-Zalpha2 domains of Z-DNA binding protein 1
Sep 02, 2024 - 2:54 AM - by nmrlearner
nmrlearner's Avatar Solution NMR backbone assignment of the N-terminal tandem Zalpha1-Zalpha2 domains of Z-DNA binding protein 1

The detection of nucleic acids that are present in atypical conformations is a crucial trigger of the innate immune response. Human Z-DNA binding protein 1 (ZBP1) is a pattern recognition receptor that harbors two Z? domains that recognize Z-DNA and Z-RNA. ZBP1 detects this alternate nucleic acid conformation as foreign, and upon stabilization of these substrates, it triggers activation of an immune response. Here, we present the backbone chemical shift assignment of a construct encompassing the...

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0 Replies | 80 Views
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