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Illuminating an invisible state of the HIV-1 capsid protein CTD dimer using - pnas.org
Mar 25, 2025 - 4:12 PM - by nmrlearner
nmrlearner's Avatar Illuminating an invisible state of the HIV-1 capsid protein CTD dimer using - pnas.org

Illuminating an invisible state of the HIV-1 capsid protein CTD dimer using pnas.org Read here
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Anisotropic Dynamics of Protein Side Chain NH - ACS Publications
Mar 25, 2025 - 4:12 PM - by nmrlearner
nmrlearner's Avatar Anisotropic Dynamics of Protein Side Chain NH - ACS Publications

Anisotropic Dynamics of Protein Side Chain NH ACS Publications Read here
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A Hybrid Nanotube Stamp System in Intracellular Protein Delivery for Cancer Treatment and NMR Analytical Techniques | Analytical Chemistry - ACS Publications
Mar 25, 2025 - 4:01 AM - by nmrlearner
nmrlearner's Avatar A Hybrid Nanotube Stamp System in Intracellular Protein Delivery for Cancer Treatment and NMR Analytical Techniques | Analytical Chemistry - ACS Publications

A Hybrid Nanotube Stamp System in Intracellular Protein Delivery for Cancer Treatment and NMR Analytical Techniques | Analytical Chemistry ACS Publications Read here
0 Replies | 27 Views
Are Protein Force Fields Getting Better? A Systematic Benchmark on 524 Diverse NMR Measurements - ACS Publications
Mar 25, 2025 - 4:01 AM - by nmrlearner
nmrlearner's Avatar Are Protein Force Fields Getting Better? A Systematic Benchmark on 524 Diverse NMR Measurements - ACS Publications

Are Protein Force Fields Getting Better? A Systematic Benchmark on 524 Diverse NMR Measurements ACS Publications Read here
0 Replies | 24 Views
[NMR paper] Quantifying protein-drug lifetimes in human cells by (19)F NMR spectroscopy
Mar 25, 2025 - 4:01 AM - by nmrlearner
nmrlearner's Avatar Quantifying protein-drug lifetimes in human cells by (19)F NMR spectroscopy

The cellular environment is a complex and crowded space, with organelles, compartments and multitudes of molecules engaged in intricate networks of communication that modulate binary protein-ligand/protein interactions. As a result, it is becoming increasingly appreciated that evaluations of protein-drug binding should be carried out in the native cellular environment. Here, we present a proof-of-concept study where we measured the lifetime (1/k(off)) of a protein-drug complex in human cells by...

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0 Replies | 111 Views
[NMR paper] Solution Structure and NMR Chemical Shift Perturbations of the Arabidopsis BCCP1 Identify Intersubunit Interactions Potentially Involved in the Assembly of the Heteromeric Acetyl-CoA Carboxylase
Mar 25, 2025 - 4:01 AM - by nmrlearner
nmrlearner's Avatar Solution Structure and NMR Chemical Shift Perturbations of the Arabidopsis BCCP1 Identify Intersubunit Interactions Potentially Involved in the Assembly of the Heteromeric Acetyl-CoA Carboxylase

Biotin carboxyl carrier protein (BCCP) is a subunit of the heteromeric acetyl-CoA carboxylase (htACCase), and it chemically links the two half-reactions that constitute the formation of malonyl-CoA from acetyl-CoA, a critical reaction in fatty acid biosynthesis. Because plants are a major source of edible fats and oils, it is important to understand the structural organization of the plant htACCase, relative to its potential to regulate fatty acid biosynthesis in plant plastids. Moreover, unique...

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Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy - ACS Publications
Mar 24, 2025 - 3:53 PM - by nmrlearner
nmrlearner's Avatar Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy - ACS Publications

Quantitating Metabolites in Protein Precipitated Serum Using NMR Spectroscopy ACS Publications Read here
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[NMR paper] Refolding of the Deinococcus Radiodurans phytochrome photosensory module and an extended backbone resonance assignment by solution NMR
Mar 24, 2025 - 3:53 PM - by nmrlearner
nmrlearner's Avatar Refolding of the Deinococcus Radiodurans phytochrome photosensory module and an extended backbone resonance assignment by solution NMR

Solution NMR reveals the structure and dynamics of biomolecules in solution. In particular, the method can detect changes due to perturbation of the molecules, without limiting effects of frozen particles or crystal environments. Phytochromes are photosensors which control the response to red/far-red light in bacteria, fungi and plants, undergo specific structural changes when photoactivated from the Pr to the Pfr state. While structures of phytochromes have been revealed in both states, the...

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