Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins Science AdvancesIn every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of the evolution of new ...
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01-07-2019 05:49 AM
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli - Science Advances
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli - Science Advances
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli Science AdvancesWith the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an ...
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01-07-2019 05:49 AM
Blind protein structure prediction using accelerated free-energy simulations - Science Advances
Blind protein structure prediction using accelerated free-energy simulations - Science Advances
Blind protein structure prediction using accelerated free-energy simulations Science AdvancesWe report a key proof of principle of a new acceleration method for predicting protein structures by molecular ...
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01-07-2019 05:49 AM
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli - Science Advances
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli - Science Advances
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Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli
Science Advances
The NMR structure of LptA complexed with thanatin, reported here, superimposed upon the crystal structure of the LptA head-to-tail oligomer (PDB 2R1A), reveals that the thanatin binding site overlaps and would therefore block the interaction between ...
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11-25-2018 06:02 AM
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation - Science Advances
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation - Science Advances
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The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
Science Advances
We further speculated that the peak disappearances might also be caused either by the formation of a multimeric complex that is too large to be detected in the NMR experiments (although no precipitation was visible in the NMR titration experiments) or, ...
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07-06-2018 09:40 AM
Neutron Crystallography Detects Differences in ProteinDynamics: Structure of the PKG II Cyclic Nucleotide Binding Domainin Complex with an Activator
Neutron Crystallography Detects Differences in ProteinDynamics: Structure of the PKG II Cyclic Nucleotide Binding Domainin Complex with an Activator
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00010/20180312/images/medium/bi-2018-00010h_0003.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00010
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/F7_wnrZBMNw
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03-13-2018 07:39 PM
Protein Science by DNA Sequencing: How Advances in Molecular Biology Are Accelerating Biochemistry
Protein Science by DNA Sequencing: How Advances in Molecular Biology Are Accelerating Biochemistry
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00886/20171020/images/medium/bi-2017-008868_0004.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00886
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/vJJECwRnRgQ
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10-24-2017 01:41 AM
[NMR paper] Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
J Biomol NMR. 2013 Mar 3;
Authors: Hennig J, Wang I, Sonntag M, Gabel F, Sattler M
Abstract
Many processes in the regulation of gene expression and signaling involve the formation of protein complexes involving multi-domain proteins. Individual domains that mediate protein-protein and protein-nucleic...