An in vivo platform for identifying inhibitors of protein aggregation - Nature.com
An in vivo platform for identifying inhibitors of protein aggregation - Nature.com
Nature.com An in vivo platform for identifying inhibitors of protein aggregation Nature.com
We show that the system can be used to detect aggregation-prone sequences and to screen for inhibitors that prevent protein aggregation, using as examples human and rat islet amyloid polypeptide (hIAPP and rIAPP, respectively), amyloid β1â??40 (Aβ40 ...
Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ... - Nature.com
Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ... - Nature.com
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Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ...
Nature.com
The 1H and 13C NMR spectra (in acetone-d6) showed 23 proton and 16 carbon signals (Table 1) that were classified into one methyl, eight sp3 methylene, two sp3 oxygenated methine, two sp2 methine, two sp2 quaternary and one carbonyl carbons through ...
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04-22-2015 03:33 PM
Protein aggregation Curling damage - Nature.com
Protein aggregation Curling damage - Nature.com
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Protein aggregation Curling damage
Nature.com
... misfolded proteins was induced. CsgC could inhibit CsgA amyloid formation in vitro, as detected by far-UV CD spectroscopy and NMR, presumably by stabilizing a preamyloid intermediate of CsgA, as detected by an amyloid conformation-specific antibody.
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02-18-2015 06:15 PM
[NMR paper] Identifying Critical Unrecognized Sugar - Protein Interactions in GH10 Xylanases from Geobacillus stearothermophilus Using STD NMR.
Identifying Critical Unrecognized Sugar - Protein Interactions in GH10 Xylanases from Geobacillus stearothermophilus Using STD NMR.
Related Articles Identifying Critical Unrecognized Sugar - Protein Interactions in GH10 Xylanases from Geobacillus stearothermophilus Using STD NMR.
FEBS J. 2013 Jul 17;
Authors: Balazs YS, Lisitsin E, Carmiel O, Shoham G, Shoham Y, Schmidt A
Abstract
(1) H solution NMR spectroscopy is used synergistically with three-dimensional crystallographic structures to map experimentally significant hydrophobic...
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07-19-2013 09:20 PM
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
Mini Rev Med Chem. 2011 Jan 11;
Authors: Pons J, Tanchou V, Girault JP, Bertho G, Evrard-Todeschi N
Without crystallographic data, NMR has emerged as the best way to define protein-ligand interactions. Using NMR experiments based on magnetization transfer, one can select molecules bound, estimate the dissociation constant, identify contacts implied in the binding, obtain a structure of the bound ligand and make...
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01-13-2011 12:00 PM
[NMR paper] NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP.
NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP.
Related Articles NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP.
Peptides. 2006 Jan;27(1):194-210
Authors: Evrard-Todeschi N, Gharbi-Benarous J, Bertho G, Coadou G, Megy S, Benarous R, Girault JP
The human immunodeficiency virus type 1 (HIV-1) Vpu enhances viral particle release and, its interaction with the ubiquitin ligase SCF-beta-TrCP triggers the HIV-1...
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12-01-2010 06:56 PM
[NMR paper] NMR techniques for identifying the interface of a larger protein-protein complex: cro
NMR techniques for identifying the interface of a larger protein-protein complex: cross-saturation and transferred cross-saturation experiments.
Related Articles NMR techniques for identifying the interface of a larger protein-protein complex: cross-saturation and transferred cross-saturation experiments.
Methods Enzymol. 2005;394:483-506
Authors: Shimada I
NMR provides detailed structural information for protein complexes with molecular weights up to 30 kDa. However, it is difficult to obtain such information on larger proteins using NMR. To...
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11-24-2010 11:14 PM
[NMR paper] An integrated platform for automated analysis of protein NMR structures.
An integrated platform for automated analysis of protein NMR structures.
Related Articles An integrated platform for automated analysis of protein NMR structures.
Methods Enzymol. 2005;394:111-41
Authors: Huang YJ, Moseley HN, Baran MC, Arrowsmith C, Powers R, Tejero R, Szyperski T, Montelione GT
Recent developments provide automated analysis of NMR assignments and three-dimensional (3D) structures of proteins. These approaches are generally applicable to proteins ranging from about 50 to 150 amino acids. In this chapter, we summarize progress...
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11-24-2010 11:14 PM
[NMR paper] NMR spectroscopy techniques for screening and identifying ligand binding to protein r
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors.
Related Articles NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors.
Angew Chem Int Ed Engl. 2003 Feb 24;42(8):864-90
Authors: Meyer B, Peters T
Binding events of ligands to receptors are the key for an understanding of biological processes. Gaining insight into protein-protein and protein-ligand interactions in solution has recently become possible on an atomic level by new NMR spectroscopic techniques....
An in vivo platform for identifying inhibitors of protein aggregation - Nature.com
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