[NMR paper] NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions-NMR waterLOGSY
NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions-NMR waterLOGSY
In drug development programmes, multiple assays are needed for the determination of protein-compound interactions and evaluation of potential use in assays with protein-protein interactions. In this protocol we describe the waterLOGSY NMR method for confirming protein-ligand binding events.
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[NMR paper] Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques.
Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques.
Related Articles Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques.
Sci Rep. 2017 Mar 30;7:45514
Authors: Yang H, Liu J, Huang Y, Gao R, Tang B, Li S, He J, Li H
Abstract
Alisertib (MLN8237) is an orally administered inhibitor of Aurora A kinase. This small-molecule inhibitor is under...
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[NMR paper] Use of (1)h-nmr std, waterlogsy and langmuir monolayer techniques for characterization of drug- zein protein complexes.
Use of (1)h-nmr std, waterlogsy and langmuir monolayer techniques for characterization of drug- zein protein complexes.
Related Articles Use of (1)h-nmr std, waterlogsy and langmuir monolayer techniques for characterization of drug- zein protein complexes.
Eur J Pharm Biopharm. 2013 Jul 24;
Authors: Sousa FF, Luzardo-Álvarez A, Blanco-Méndez J, Otero-Espinar FJ, Martín-Pastor M, Sandez Macho I
Abstract
Zein is a protein based natural biopolymer containing a large amount of nonpolar amino acids, which has shown the ability to form...
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Use of 1h-nmr std, waterlogsy and langmuir monolayer techniques for characterization of drug- zein protein complexes
Use of 1h-nmr std, waterlogsy and langmuir monolayer techniques for characterization of drug- zein protein complexes
Publication date: Available online 24 July 2013
Source:European Journal of Pharmaceutics and Biopharmaceutics</br>
Author(s): F.F.O. Sousa , A. Luzardo-Álvarez , J. Blanco-Méndez , F.J. Otero-Espinar , M. Martín-Pastor , I. Sandez Macho</br>
Zein is a protein based natural biopolymer containing a large amount of nonpolar amino acids, which has shown the ability to form aggregates and entrap solutes, such as drugs and amino acids to form stable...
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NMR techniques in drug delivery: Application to zein protein complexes
NMR techniques in drug delivery: Application to zein protein complexes
15 December 2012
Publication year: 2012
Source:International Journal of Pharmaceutics, Volume 439, Issues 1–2</br>
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Zein is a protein containing a large amount of nonpolar amino acids, which has shown the ability to form aggregates and entrap solutes, such as drugs and amino acids. NMR techniques were used to detect binding interactions and measure affinity between zein and three different drugs: tetracycline, amoxicillin and indomethacin. The release study of zein microparticle formulations...
Use of 1H NMR STD, WaterLOGSY, and Langmuir monolayer techniques for characterization of drug–zein protein ... - ScienceDirect.com
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