UMass Amherst Biochemists Simulate a Protein-Folding Chaperone's Functional Dance - UMass News and Media Relations

		BioNMR > NMR community > Online News
UMass Amherst Biochemists Simulate a Protein-Folding Chaperone's Functional Dance - UMass News and Media Relations

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

08-29-2017, 05:35 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

UMass Amherst Biochemists Simulate a Protein-Folding Chaperone's Functional Dance - UMass News and Media Relations

UMass News and Media Relations

UMass Amherst Biochemists Simulate a Protein-Folding Chaperone's Functional Dance
UMass News and Media Relations
Gierasch says Wenli Meng, a master of nuclear magnetic resonance (NMR) techniques, obtained NMR data that validated the simulations. The linker is just 12 amino acids long, and Meng was able to directly extract linker information from among 636 amino ...

and more »

UMass Amherst Biochemists Simulate a Protein-Folding Chaperone's Functional Dance - UMass News and Media Relations
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Protein folding: Much more intricate than we thought - Chemical & Engineering News Protein folding: Much more intricate than we thought - Chemical & Engineering News http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcR2lUbQznmJikp64yONmq-93HLAx2q0s7eusWw6aVTxD8SqPlpjnTY-svt66vvMTtugAbUWrjzO Chemical & Engineering News <img alt="" height="1" width="1"> Protein folding: Much more intricate than we thought Chemical & Engineering News In 2014, a team led by Kalodimos reported an NMR-based structure of Trigger Factor showing that it binds to an unfolded peptide in at least four spots where the peptide has stretches of six to 10 hydrophobic residues (Science, DOI:...	nmrlearner	Online News	0	07-31-2017 11:54 AM
[NMR paper] Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Related Articles Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation. Proc Natl Acad Sci U S A. 2016 Jun 13; Authors: Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C Abstract Curli, consisting primarily of major structural subunit CsgA, are functional amyloids produced on the surface of...	nmrlearner	Journal club	0	06-15-2016 11:12 PM
A DsbA-Deficient Periplasm Enables Functional Display of a Protein with Redox-Sensitive Folding on M13 Phage A DsbA-Deficient Periplasm Enables Functional Display of a Protein with Redox-Sensitive Folding on M13 Phage http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00392/20160601/images/medium/bi-2016-003924_0004.gif Biochemistry DOI: 10.1021/acs.biochem.6b00392 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/rohgQg9bBbs More...	nmrlearner	Journal club	0	06-02-2016 02:11 AM
[NMR paper] NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation. NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation. Related Articles NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation. Protein Sci. 2013 Dec 4; Authors: Garrison MA, Crowhurst KA Abstract HdeA is a periplasmic chaperone...	nmrlearner	Journal club	0	01-01-2014 03:05 PM
NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation Abstract HdeA is a periplasmic chaperone found in several gram-negative pathogenic bacteria that are linked to millions of cases of dysentery per year worldwide. After the protein becomes activated at low pH, it can bind to other periplasmic proteins, protecting them from aggregation when the bacteria travel through the stomach on their way to colonize the intestines. It has been...	nmrlearner	Journal club	0	12-24-2013 01:04 PM
NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation Abstract HdeA is a periplasmic chaperone found in several gram-negative pathogenic bacteria that are linked to millions of cases of dysentery per year worldwide. After the protein becomes activated at low pH, it can bind to other periplasmic proteins, protecting them from aggregation when the bacteria travel through the stomach on their way to colonize the intestines. It has been...	nmrlearner	Journal club	0	12-04-2013 03:12 PM
Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net <img alt="" height="1" width="1" /> Biochemists reveal interaction between tumor suppressor protein and chaperone News-Medical.net Using nuclear magnetic resonance (NMR) spectroscopy, the scientists at the Bavarian NMR Center in Garching were able for the first time to characterize the interaction surfaces between Hsp90 and p53 and show that p53 binds to Hsp90 in an already ... Read here	nmrlearner	Online News	0	09-08-2011 08:24 AM
[NMR tweet] Director of UMass Nuclear Magnetic Resonance Lab Dr. Weiguo Hu talks with students about "comfort with difference" http://twitpic.com/3tx3te Director of UMass Nuclear Magnetic Resonance Lab Dr. Weiguo Hu talks with students about "comfort with difference" http://twitpic.com/3tx3te Published by TheWillistonNS (WillistonNorthampton) on 2011-01-27T17:44:44Z Source: Twitter	nmrlearner	Twitter NMR	0	01-27-2011 05:54 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off