Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com

		BioNMR > NMR community > Online News
Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

01-29-2023, 07:06 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,733

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com

Targeting protein phosphatases in cancer immunotherapy and ... - Nature.com

Targeting protein phosphatases in cancer immunotherapy and ... Nature.com Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Structural basis of bacterial effector protein azurin targeting tumor ... - Nature.com Structural basis of bacterial effector protein azurin targeting tumor ... - Nature.com Structural basis of bacterial effector protein azurin targeting tumor ... Nature.com Read here	nmrlearner	Online News	0	01-17-2023 09:17 PM
Deubiquitinase-targeting chimeras for targeted protein stabilization - Nature.com Deubiquitinase-targeting chimeras for targeted protein stabilization - Nature.com Deubiquitinase-targeting chimeras for targeted protein stabilization Nature.com Read here	nmrlearner	Online News	0	09-18-2022 04:17 PM
[NMR paper] New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies Benzimidazole derivatives are known to be key players in the development of novel anticancer agents. Herein, we aimed to synthesize novel derivatives to target breast cancer. A new series of benzimidazole derivatives conjugated with either six- and five-membered heterocyclic ring or pyrazanobenzimidazoles and pyridobenzimidazole linkers were synthesized yielding compounds 5-8 and 10-14, respectively. Structure elucidation of the newly synthesized compounds was achieved through...	nmrlearner	Journal club	0	08-30-2022 08:26 PM
New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein \| Scientific Reports - Nature.com New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein \| Scientific Reports - Nature.com New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein \| Scientific Reports Nature.com Read here	nmrlearner	Online News	0	08-09-2022 01:50 PM
[ASAP] Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.0c00841/20210115/images/medium/bi0c00841_0004.gif Biochemistry DOI: 10.1021/acs.biochem.0c00841 http://feeds.feedburner.com/~r/acs/bichaw/~4/VnMZ9jCKgw8 More...	nmrlearner	Journal club	0	01-16-2021 04:55 PM
Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer - Science Advances Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer - Science Advances Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer Science Advances Read here	nmrlearner	Online News	0	02-29-2020 09:52 PM
[NMR paper] X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases. X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases. X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases. Methods. 2013 Jul 27; Authors: Elena Gulerez I, Gehring K Abstract Protein tyrosine phosphatases (PTPs) are well recognized as key targets in a wide spectrum of diseases, such as diabetes, obesity and cancer. Their roles in these maladies have been successfully characterized by various methods. However, it is only by utilizing the entire gamut of tools and techniques...	nmrlearner	Journal club	0	08-01-2013 12:56 PM
X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases Publication date: Available online 27 July 2013 Source:Methods</br> Author(s): Irina Elena Gulerez , Kalle Gehring</br> Protein tyrosine phosphatases (PTPs) are well recognized as key targets in a wide spectrum of diseases, such as diabetes, obesity and cancer. Their roles in these maladies have been successfully characterized by various methods. However, it is only by utilizing the entire gamut of tools and techniques available that we can build a sufficient knowledge of their...	nmrlearner	Journal club	0	07-28-2013 07:11 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off