'Sushi-like' nanodiscs provide structural snapshots of misfolding proteins - News-Medical.net

		BioNMR > NMR community > Online News
'Sushi-like' nanodiscs provide structural snapshots of misfolding proteins - News-Medical.net

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

12-16-2017, 08:11 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

'Sushi-like' nanodiscs provide structural snapshots of misfolding proteins - News-Medical.net

'Sushi-like' nanodiscs provide structural snapshots of misfolding proteins - News-Medical.net

News-Medical.net

'Sushi-like' nanodiscs provide structural snapshots of misfolding proteins
News-Medical.net
In the ocean, there are no boundaries; a swimming pool has boundaries," Ramamoorthy said. "We're able to stop the aggregation of the protein in this restricted membrane environment so we can monitor what it looks like before it becomes a mass of fibers ...

and more »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Nanodiscs catch misfolding proteins red-handed - EurekAlert (press release) Nanodiscs catch misfolding proteins red-handed - EurekAlert (press release) <img alt="" height="1" width="1"> Nanodiscs catch misfolding proteins red-handed EurekAlert (press release) "We're able to stop the aggregation of the protein in this restricted membrane environment so we can monitor what it looks like before it becomes a mass of fibers." At this point, the researchers use a technique called nuclear magnetic resonance ... Read here	nmrlearner	Online News	0	12-15-2017 09:07 PM
Nanodiscs catch misfolding proteins red-handed - Infosurhoy Nanodiscs catch misfolding proteins red-handed - Infosurhoy <img alt="" height="1" width="1"> Nanodiscs catch misfolding proteins red-handed Infosurhoy â??We're able to stop the aggregation of the protein in this restricted membrane environment so we can monitor what it looks like before it becomes a mass of fibers.â?? At this point, the researchers use a technique called nuclear magnetic resonance ... Read here	nmrlearner	Online News	0	12-10-2017 01:21 AM
[NMR paper] Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan;13(1):79-98 Authors: Hagn F, Nasr ML, Wagner G Abstract Suitable membrane mimetics are crucial to the performance of structural and functional studies of membrane proteins. Phospholipid nanodiscs (formed when a membrane scaffold protein encircles a small portion of a lipid bilayer) have...	nmrlearner	Journal club	0	12-08-2017 02:25 PM
Nano 'sushi' catch toxic amyloids in action - Futurity - Futurity: Research News http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcRqfikrnyQk1Td0KvdrLts1wuF_NBKxv-XYq9wnqegmXtaY-C413UMW6FIW1FdKrDOzm7dj5K4s Futurity: Research News <img alt="" height="1" width="1"> Nano 'sushi' catch toxic amyloids in action - Futurity Futurity: Research News Clumps of misfolded proteins, called plaques or amyloid fibers, are implicated in many diseases: Alzheimer's, Parkinson's, and type 2 diabetes. and more » Nano 'sushi' catch toxic amyloids in action - Futurity - Futurity: Research News	nmrlearner	Online News	0	12-06-2017 11:04 PM
Nanodiscs catch misfolding proteins red-handed - Phys.org - Phys.Org Nanodiscs catch misfolding proteins red-handed - Phys.org - Phys.Org <img alt="" height="1" width="1"> Nanodiscs catch misfolding proteins red-handed - Phys.org Phys.Org When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins ... and more » Read here	nmrlearner	Online News	0	12-06-2017 11:04 PM
Nanodiscs catch misfolding proteins - Xinhua Nanodiscs catch misfolding proteins - Xinhua <img alt="" height="1" width="1"> Nanodiscs catch misfolding proteins Xinhua "We're able to stop the aggregation of the protein in this restricted membrane environment so we can monitor what it looks like before it becomes a mass of fibers," said lead researcher Ayyalusamy Ramamoorthy, UM professor of biophysics and chemistry ... Read here	nmrlearner	Online News	0	12-06-2017 08:02 AM
What is Structural Genomics? - News-Medical.net http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcTc7BTZDAqNY9IP0XKaT3YgQ5rHzjRoKeElI2zGkLtcvYg2WazMaMDnRUTChYpJ8Ma5z9lytBh8 News-Medical.net <img alt="" height="1" width="1"> What is Structural Genomics? News-Medical.net The purified and crystallized proteins can be analyzed with X-ray crystallography or Nuclear Magnetic Resonance. This allows the structure of every protein encoded by the genome to be determined. Ab initio modeling: information about the protein ... What is Structural Genomics? - News-Medical.net	nmrlearner	Online News	0	03-09-2017 12:11 AM
Researchers solve complete 3-D structure of E6 proteins in HPV 16 - News-Medical.net Researchers solve complete 3-D structure of E6 proteins in HPV 16 - News-Medical.net <img alt="" height="1" width="1" /> Researchers solve complete 3-D structure of E6 proteins in HPV 16 News-Medical.net Success depended on two factors: the development of methods for isolating protein E6 as well as the use of nuclear magnetic resonance (NMR) and crystallography techniques. Having dealt with various aggregation and purification problems, the researchers ... and more » Read here	nmrlearner	Online News	0	02-16-2013 05:53 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off