Study reveals insights into protein linked to cancer and Alzheimer's disease - Phys.Org

		BioNMR > NMR community > Online News
Study reveals insights into protein linked to cancer and Alzheimer's disease - Phys.Org

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

06-07-2016, 12:27 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Study reveals insights into protein linked to cancer and Alzheimer's disease - Phys.Org

Phys.Org

Study reveals insights into protein linked to cancer and Alzheimer's disease
Phys.Org
Using high-field nuclear magnetic resonance (NMR) spectroscopy, Peng and his group propose answers to both questions. He explained with a metaphor. "When Pin 1 is by itself, its two domains, call them 'A' and 'B,' have greater physical contact," he said.

and more »

Study reveals insights into protein linked to cancer and Alzheimer's disease - Phys.Org
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Study reveals insights into protein linked to cancer, Alzheimer's disease - Science Daily Study reveals insights into protein linked to cancer, Alzheimer's disease - Science Daily <img alt="" height="1" width="1"> Study reveals insights into protein linked to cancer, Alzheimer's disease Science Daily NMR-based model for Pin1 (â??Aâ?? and â??Bâ?? globular domains), and its interaction with its â??disorderedâ?? protein targets pertinent to cancer and Alzheimer's disease (green). The Pin1 â??Aâ?? and â??Bâ?? domains specialize in peptidyl-prolyl isomerase activity and ... Read here	nmrlearner	Online News	0	06-05-2016 02:18 AM
Study reveals insights into protein linked to cancer and Alzheimer's disease - ND Newswire http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcSIEIFHvN6wSSfDhV3FRW2RysVGw70jeqtPX6kqekedo4rSL4MKJDugtd0x7ybXwVV7oDG_T8s ND Newswire <img alt="" height="1" width="1"> Study reveals insights into protein linked to cancer and Alzheimer's disease ND Newswire Using high-field nuclear magnetic resonance (NMR) spectroscopy, Peng and his group propose answers to both questions. He explained with a metaphor. â??When Pin 1 is by itself, its two domains, call them 'A' and 'B,' have greater physical contact,â?? he said. and more » Study reveals insights into protein linked to...	nmrlearner	Online News	0	06-03-2016 04:52 PM
Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release) Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release) <img alt="" height="1" width="1"> Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease Newswise (press release) Yet they are increasingly recognized as functional units, figuring prominently in cancer-related proteins. So a second question has been, how does Pin1 interact with those disordered sites? Using high-field nuclear magnetic resonance (NMR) spectroscopy ... and more » Read here	nmrlearner	Online News	0	06-03-2016 04:52 PM
Study of PEGylated model protein reveals porous structure based on PEG size - Phys.Org Study of PEGylated model protein reveals porous structure based on PEG size - Phys.Org http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcQdT1VtDs_349GghNDjMV50tdw7g0UzZNnkRkMt-SgVH2a6hHSvjT8JY4N42n5PGHBQ_JntWNc Phys.Org <img alt="" height="1" width="1"> Study of PEGylated model protein reveals porous structure based on PEG size Phys.Org NMR studies using 1H-15N heteronuclear single-quantum correlation spectroscopy showed that the PEG-Pc had well-dispersed resonances that indicated the protein remained folded in a stable conformation. Chemical shift perturbations were only...	nmrlearner	Online News	0	09-22-2015 06:40 PM
Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com <img alt="" height="1" width="1"> Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... Nature.com Volumes of the hippocampi and entorhinal cortices in the ANM cohort were obtained using FreeSurfer 5.1.0 (freely available from http://surfer.nmr.mgh.harvard.edu/) from 276 ANM subjects who had undergone structural MRI. These regions were selected as ... Read here	nmrlearner	Online News	0	06-17-2015 08:01 AM
Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com <img alt="" height="1" width="1"> Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... Nature.com Volumes of the hippocampi and entorhinal cortices in the ANM cohort were obtained using FreeSurfer 5.1.0 (freely available from http://surfer.nmr.mgh.harvard.edu/) from 276 ANM subjects who had undergone structural MRI. These regions were selected as ... Read here	nmrlearner	Online News	0	06-16-2015 07:24 PM
[NMR paper] Pyruvate carboxylase and pentose phosphate fluxes are reduced in A?PP-PS1 mouse model of Alzheimer's disease: a ¹³C NMR study. Pyruvate carboxylase and pentose phosphate fluxes are reduced in A?PP-PS1 mouse model of Alzheimer's disease: a ¹³C NMR study. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--iospress.metapress.com-images-ios-pubmed.gif Related Articles Pyruvate carboxylase and pentose phosphate fluxes are reduced in A?PP-PS1 mouse model of Alzheimer's disease: a ¹³C NMR study. J Alzheimers Dis. 2014;41(2):387-99 Authors: Tiwari V, Patel AB Abstract Although pyruvate dehydrogenase (PDH) is the major pathway of glucose...	nmrlearner	Journal club	0	02-11-2015 04:19 PM
[NMR tweet] NMR for celiac disease: metabonomic insights: A nuclear magnetic resonance spectroscopic approach to the disease... http://bit.ly/ffTXaC NMR for celiac disease: metabonomic insights: A nuclear magnetic resonance spectroscopic approach to the disease... http://bit.ly/ffTXaC Published by pritihonrao (Priti Honrao) on 2011-01-05T02:32:56Z Source: Twitter	nmrlearner	Twitter NMR	0	01-05-2011 02:40 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off