Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release)

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Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release)

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MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

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Protein geomtery:

SAVES2 or SAVES4

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FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

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Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

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06-03-2016, 04:52 PM

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Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release)

Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release)

Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease
Newswise (press release)
Yet they are increasingly recognized as functional units, figuring prominently in cancer-related proteins. So a second question has been, how does Pin1 interact with those disordered sites? Using high-field nuclear magnetic resonance (NMR) spectroscopy ...

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