Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances

		BioNMR > NMR community > Online News
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-25-2019, 05:39 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,715

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins Science AdvancesIn every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of the evolution of new ...

Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins - Science Advances Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins Science AdvancesIn every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of the evolution of new ... Read here	nmrlearner	Online News	0	01-07-2019 05:49 AM
[NMR paper] Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation. Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation. Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation. Prog Nucl Magn Reson Spectrosc. 2017 Nov;102-103:43-60 Authors: Salvi N, Abyzov A, Blackledge M Abstract Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful experimental approaches for investigating the conformational behaviour of intrinsically disordered proteins (IDPs). IDPs represent a significant...	nmrlearner	Journal club	0	11-22-2017 02:01 PM
[NMR paper] Analytical description of NMR relaxation highlights correlated dynamics in intrinsically disordered proteins. Analytical description of NMR relaxation highlights correlated dynamics in intrinsically disordered proteins. Related Articles Analytical description of NMR relaxation highlights correlated dynamics in intrinsically disordered proteins. Angew Chem Int Ed Engl. 2017 Aug 22;: Authors: Blackledge M, Salvi N, Abyzov A Abstract The dynamic fluctuations of intrinsically disordered proteins (IDPs) define their function. Although experimental nuclear magnetic resonance (NMR) relaxation reveals the motional complexity of these highly...	nmrlearner	Journal club	0	08-25-2017 04:11 AM
[NMR paper] Analytical description of NMR relaxation highlights correlated dynamics in intrinsically disordered proteins Analytical description of NMR relaxation highlights correlated dynamics in intrinsically disordered proteins The dynamic fluctuations of intrinsically disordered proteins (IDPs) define their function. Although experimental nuclear magnetic resonance (NMR) relaxation reveals the motional complexity of these highly flexible proteins, the absence of physical models describing IDP dynamics hinders their mechanistic interpretation. Combining molecular dynamics simulation and NMR, we introduce a framework in which distinct motions are attributed to local libration, backbone dihedral angle...	nmrlearner	Journal club	0	08-23-2017 03:18 AM
Atomic Resolution Conformational Dynamics of Intrinsically Disordered Proteins from NMR Spin Relaxation Atomic Resolution Conformational Dynamics of Intrinsically Disordered Proteins from NMR Spin Relaxation Publication date: Available online 10 July 2017 Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br> Author(s): Nicola Salvi, Anton Abyzov, Martin Blackledge</br> Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful experimental approaches for investigating the conformational behavior of intrinsically disordered proteins (IDPs). IDPs represent a significant fraction of all proteomes, and, despite their importance for...	nmrlearner	Journal club	0	07-11-2017 09:20 AM
[NMR paper] Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation. Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation. Related Articles Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation. J Phys Chem Lett. 2016 Jun 14; Authors: Salvi N, Abyzov A, Blackledge M Abstract Intrinsically disordered proteins (IDPs) access highly diverse ensembles of conformations in their functional states. Although this plasticity is essential to their function, little is known about the dynamics underlying...	nmrlearner	Journal club	0	06-15-2016 11:12 PM
[NMR paper] NMR contributions to structural dynamics studies of intrinsically disordered proteins. NMR contributions to structural dynamics studies of intrinsically disordered proteins. Related Articles NMR contributions to structural dynamics studies of intrinsically disordered proteins. J Magn Reson. 2014 Apr;241:74-85 Authors: Konrat R Abstract Intrinsically disordered proteins (IDPs) are characterized by substantial conformational plasticity. Given their inherent structural flexibility X-ray crystallography is not applicable to study these proteins. In contrast, NMR spectroscopy offers unique opportunities for structural and dynamic...	nmrlearner	Journal club	0	03-25-2014 11:49 AM
NMR contributions to structural dynamics studies of intrinsically disordered proteins NMR contributions to structural dynamics studies of intrinsically disordered proteins Publication date: April 2014 Source:Journal of Magnetic Resonance, Volume 241</br> Author(s): Robert Konrat</br> Intrinsically disordered proteins (IDPs) are characterized by substantial conformational plasticity. Given their inherent structural flexibility X-ray crystallography is not applicable to study these proteins. In contrast, NMR spectroscopy offers unique opportunities for structural and dynamic studies of IDPs. The past two decades have witnessed significant development...	nmrlearner	Journal club	0	03-21-2014 12:52 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off