[NMR paper] NMR spectroscopy as a characterization tool enabling biologics formulation development
NMR spectroscopy as a characterization tool enabling biologics formulation development
This review highlights recent advancements in using high resolution nuclear magnetic resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation development, meeting a current need in the biopharmaceutical industry. Conformational changes of protein therapeutics during formulation development can result in various protein-protein and protein-excipient interactions, which can lead to physical aggregation and/or chemical degradation. Innovative analytical techniques...
...
nmrlearner
Journal club
0
10-31-2022 04:08 PM
[NMR paper] Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
Novel unimolecular bivalent glycoconjugates were assembled combining several functionalized capsular polysaccharides of Streptococcus pneumoniae and Neisseria meningitidis to a carrier protein by using an effective strategy based on the Ugi 4-component reaction. The development of multivalent glycoconjugates opens new opportunities in the field of vaccine design, but their high structural complexity involves new analytical challenges. Nuclear Magnetic Resonance has found wide applications...
[NMR paper] NMR characterization of a multi-valent conjugate vaccine against Neisseria meningitidis A, C, W, Y and Haemophilus influenzae b infections
NMR characterization of a multi-valent conjugate vaccine against Neisseria meningitidis A, C, W, Y and Haemophilus influenzae b infections
Physicochemical technologies are a powerful tool for the structural characterization of vaccine antigens both at bulk level as well as on the final formulation. High-field Nuclear Magnetic Resonance (NMR) spectroscopy has been found to be an extremely and robust tool for tracking the industrial process manufacturing of carbohydrate-based vaccines. I have applied NMR spectroscopy to the characterization of a penta-valent conjugate vaccine against...
ASU center seeks potential vaccine for tularemia - Vaccine News Daily
http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcQ6qKuM7cxI6KDroGjcLdFAIb5kokLOd6-Ve2yUtfausAAPL6vw90fIm0s8-2aY8hSYZvCnQxil
Vaccine News Daily
<img alt="" height="1" width="1">
ASU center seeks potential vaccine for tularemia
Vaccine News Daily
Fromme and her ASU colleagues used nuclear magnetic resonance (NMR) spectroscopy to explore detailed features of the bacteria's surface protein. Their research marks the first structural determination at atomic scale for any lipoprotein of the genus ...
ASU center seeks potential vaccine for tularemia - Vaccine News Daily
nmrlearner
Online News
0
06-23-2015 11:58 PM
[NMR paper] Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease.
Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease.
Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease.
Molecules. 2013;18(5):4929-41
Authors: Ramírez-Gualito K, Richter M, Matzapetakis M, Singer D, Berger S
Abstract
Rational design of peptide vaccines becomes important for the treatment of some diseases such as Alzheimer's disease (AD) and related disorders. In this study, as part of a larger...
nmrlearner
Journal club
0
04-30-2013 10:21 PM
Nature and Structure of Aluminum Surface Sites Grafted on Silica from a Combination of High-Field Aluminum-27 Solid-State NMR Spectroscopy and First-Principles Calculations
Nature and Structure of Aluminum Surface Sites Grafted on Silica from a Combination of High-Field Aluminum-27 Solid-State NMR Spectroscopy and First-Principles Calculations
Rachel Nathaniel Kerber, Anthony Kermagoret, Emmanuel Callens, Pierre Florian, Dominique Massiot, Anne Lesage, Christophe Cope?ret, Franc?oise Delbecq, Xavier Rozanska and Philippe Sautet
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja3008566/aop/images/medium/ja-2012-008566_0006.gif
Journal of the American Chemical Society
DOI: 10.1021/ja3008566
...
Structural characterization of a protein adsorbed on aluminum hydroxide adjuvant in vaccine formulation | npj Vaccines - Nature.com
Linear Mode
