Small heat shock protein as model for Alzheimer's medication - News-Medical.net
Small heat shock protein as model for Alzheimer's medication - News-Medical.net
News-Medical.net Small heat shock protein as model for Alzheimer's medication News-Medical.net
Using a refined procedure of solid-state nuclear magnetic resonance spectroscopy (solid-state NMR), they managed, for the first time ever, to identify the sites in the alpha-B-crystallin that attach to the beta-amyloid. It is the first direct structure ...
Using ITC Technique for Characterization of Protein-Protein Interactions - News-Medical.net
Using ITC Technique for Characterization of Protein-Protein Interactions - News-Medical.net
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Using ITC Technique for Characterization of Protein-Protein Interactions
News-Medical.net
With each interaction, the protein structural changes occur through specific electrostatic and van der Waals interactions, the breaking and formation of hydrogen bonds and the burial of surfaces exposed to solvents. It is...
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06-24-2015 01:08 PM
Protein Purification Using Avanti JXN Series Solution - News-Medical.net
Protein Purification Using Avanti JXN Series Solution - News-Medical.net
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Protein Purification Using Avanti JXN Series Solution
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A number of proteomics applications including, in vitrobiochemical assays, mass spectrometry, NMR and X-ray crystallography involve the use of purified proteins. Proteins may be isolated through their overexpression in organisms such as yeast, bacteria ...
and...
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05-19-2015 09:10 AM
Small molecule 'could treat paralysis by triggering nerve repair' - Medical News Today
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Small molecule 'could treat paralysis by triggering nerve repair'
Medical News Today
Using nuclear magnetic resonance (NMR) technology, the team was able to closely analyze the configurations of the two p75 proteins. By introducing the p45 protein - which promotes nerve regeneration - they found it could break up the pairing of the p75 ...
Salk scientists uncover new clues to repairing an injured spinal...
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08-06-2014 08:39 PM
[NMR paper] A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
J Med Chem. 2013 Jan 30;
Authors: Dal Piaz F, Vassallo A, Temraz A, Cotugno R, Belisario MA, Bifulco G, Chini MG, Pisano C, De Tommasi N, Braca A
Abstract
The potential of Heat Shock Protein 90 (Hsp90) as a therapeutic target...
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02-03-2013 10:19 AM
Scientists determine structure of Ltn1 protein - News-Medical.net
Scientists determine structure of Ltn1 protein - News-Medical.net
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Scientists determine structure of Ltn1 protein
News-Medical.net
Ltn1 was deemed too large for its structure to be determined by current nuclear magnetic resonance (NMR) technology, and, as the scientists know now, too flexible to allow the highly regular crystalline packing needed by X-ray crystallographers. "It's ...
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01-17-2013 02:09 PM
Probing Dynamic Conformationsof the High-Molecular-Weight?B-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy
Probing Dynamic Conformationsof the High-Molecular-Weight?B-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy
Andrew J. Baldwin, Patrick Walsh, D. Flemming Hansen, Gillian R. Hilton, Justin L. P. Benesch, Simon Sharpe and Lewis E. Kay
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja307874r/aop/images/medium/ja-2012-07874r_0005.gif
Journal of the American Chemical Society
DOI: 10.1021/ja307874r
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/qcs9RnHBiBY
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09-08-2012 08:44 AM
Alzheimer's protein structure suggests new treatment directions - Eureka! Science News
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Alzheimer's protein structure suggests new treatment directions
Eureka! Science News
The Vanderbilt researchers used nuclear magnetic resonance and electron paragmagnetic resonance spectroscopy to determine the structure of C99, which has one membrane-spanning region. They were surprised to discover what appeared to be a "binding" ...
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Alzheimer's protein structure suggests new treatment directions - Eureka! Science News
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06-01-2012 07:46 AM
[NMR paper] Yeast heat shock transcription factor N-terminal activation domains are unstructured
Yeast heat shock transcription factor N-terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Yeast heat shock transcription factor N-terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy.
Protein Sci. 1996 Feb;5(2):262-9...
Small heat shock protein as model for Alzheimer's medication - News-Medical.net
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