Small Heat Shock Protein As Model for Alzheimer Medication Scicasts (press release) (blog)
As Reif and his colleagues have discovered, it binds protein types that, unlike the beta-amyloid, clump together in an unordered manner. The researchers will be supported by the new NMR Center that is currently under construction at the Garching campus ...
New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today
New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today
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Medical News Today
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New Alzheimer's treatments may arise from modeling 'heat shock proteins'
Medical News Today
Using solid-state nuclear magnetic resonance (NMR) spectroscopy, the researchers identified the exact sites in the alpha-B-crystallin structure that attach to the beta-amyloid. The achievement is the result of...
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10-13-2015 06:03 PM
Spaghetti-Like Proteins Are Surprisingly Effective 'Keys', Says Study - Scicasts (press release) (blog)
Spaghetti-Like Proteins Are Surprisingly Effective 'Keys', Says Study - Scicasts (press release) (blog)
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Scicasts (press release) (blog)
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Spaghetti-Like Proteins Are Surprisingly Effective 'Keys', Says Study
Scicasts (press release) (blog)
The ultrafast and yet selective binding allows the receptor (gold) to rapidly travel through the pore filled with disordered proteins (blue) into the nucleus, while any unwanted molecules...
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10-13-2015 06:03 PM
Small heat shock protein as model for Alzheimer's medication - News-Medical.net
Small heat shock protein as model for Alzheimer's medication - News-Medical.net
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Small heat shock protein as model for Alzheimer's medication
News-Medical.net
Using a refined procedure of solid-state nuclear magnetic resonance spectroscopy (solid-state NMR), they managed, for the first time ever, to identify the sites in the alpha-B-crystallin that attach to the beta-amyloid. It is the first direct...
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10-13-2015 05:51 AM
New Study Detects Protein Movements Even Inside Crystals - Scicasts (press release) (blog)
New Study Detects Protein Movements Even Inside Crystals - Scicasts (press release) (blog)
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Scicasts (press release) (blog)
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New Study Detects Protein Movements Even Inside Crystals
Scicasts (press release) (blog)
The researchers at IBS used a multi-technique approach, combining solid-state NMR spectroscopy, simulations of molecular dynamics and X-ray crystallography. Thanks to solid-state NMR, they were able to measure the...
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10-06-2015 10:39 PM
New Findings Explain How Molecules are Speedily Transported Into and Out of ... - Scicasts (press release) (blog)
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New Findings Explain How Molecules are Speedily Transported Into and Out of ...
Scicasts (press release) (blog)
Using a technique known as nuclear magnetic resonance spectroscopy, the researchers collected atomic-scale information about the behaviour of the FG Nups, focusing on Nsp1, the most studied representative of the FG Nups. Normally, proteins fold into ...
New Findings Explain How Molecules are Speedily Transported Into and Out of ... - Scicasts (press release) (blog)
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09-23-2015 11:52 AM
Researchers Describe Key Cellular Clockwork Behind Inflammation - Scicasts (press release) (blog)
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Researchers Describe Key Cellular Clockwork Behind Inflammation
Scicasts (press release) (blog)
Nuclear magnetic resonance-derived images depict the structures of proteins Tom1 (green) and Tollip (red). These interactive regions are required for both proteins to achieve their cooperative function. Image: Daniel Capelluto/Virginia Tech.
Researchers Describe Key Cellular Clockwork Behind Inflammation - Scicasts (press release) (blog)
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08-29-2015 09:18 PM
NeuroPhage Discovers GAIM-changing Molecules to Combat Alzheimer's ... - Virtual Press Office (press release)
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NeuroPhage Discovers GAIM-changing Molecules to Combat Alzheimer's ...
Virtual Press Office (press release)
Researchers used an array of techniques, including X-ray fiber diffraction and nuclear magnetic resonance spectroscopy, to demonstrate the activities of GAIM. They discovered that GAIM effectively binds to multiple types of misfolded proteins during ...
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NeuroPhage Discovers GAIM-changing Molecules to Combat Alzheimer's ... - Virtual Press Office (press release)
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04-24-2014 08:12 AM
[NMR paper] A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
J Med Chem. 2013 Jan 30;
Authors: Dal Piaz F, Vassallo A, Temraz A, Cotugno R, Belisario MA, Bifulco G, Chini MG, Pisano C, De Tommasi N, Braca A
Abstract
The potential of Heat Shock Protein 90 (Hsp90) as a therapeutic target...