Sleeping Sickness: Parasite's Achilles Heel Determined, Geared Towards Cure - Science Times

		BioNMR > NMR community > Online News
Sleeping Sickness: Parasite's Achilles Heel Determined, Geared Towards Cure - Science Times

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-03-2017, 01:33 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Sleeping Sickness: Parasite's Achilles Heel Determined, Geared Towards Cure - Science Times

Science Times

Sleeping Sickness: Parasite's Achilles Heel Determined, Geared Towards Cure
Science Times
The researchers were able to utilize NMR- Nuclear Magnetic Resonance in investigating the molecular structure of the two proteins. The next step was the core goal as the team determined a spatial structure that specifically binds to PEX14 preventing ...

Sleeping Sickness: Parasite's Achilles Heel Determined, Geared Towards Cure - Science Times
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
New therapeutic strategy against sleeping sickness - Phys.Org http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcTpkwhwm3nMyel38MTBAoUQYGqYskSKTfeLe5v_4QxTdQyFFgtOPOKldHY_OxTimp2w_rsyoYb3 Phys.Org <img alt="" height="1" width="1"> New therapeutic strategy against sleeping sickness Phys.Org At the Bavarian NMR Center, a joint research infrastructure of the Helmholtz Zentrum and TU MÃ¼nchen, the researchers therefore first used nuclear magnetic resonance (NMR) to investigate the structure of the two target proteins. In the next step, the ... New therapeutic strategy against sleeping sickness - Phys.Org	nmrlearner	Online News	0	03-31-2017 12:43 PM
The Achilles’ Heel of “Ultrastable”Hyperthermophile Proteins: Submillimolar Concentrations of SDS StimulateRapid Conformational Change, Aggregation, and Amyloid Formation inProteins Carrying Overall Positive Charge The Achilles’ Heel of “Ultrastable”Hyperthermophile Proteins: Submillimolar Concentrations of SDS StimulateRapid Conformational Change, Aggregation, and Amyloid Formation inProteins Carrying Overall Positive Charge http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.5b01343/20160706/images/medium/bi-2015-013433_0011.gif Biochemistry DOI: 10.1021/acs.biochem.5b01343 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/eNvtvqsdbN0 More...	nmrlearner	Journal club	0	07-07-2016 04:21 AM
Cure SMA Awards $90000 to Spinal Muscular Atrophy Researcher - SMA News Today http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcSs8xYJLXY-w1Pj8Kr3up6tvsFyZO9DnCPk9SnfLD4XcfO70cWFIojwffJkO6WNPZTLyNZb9XEs SMA News Today <img alt="" height="1" width="1"> Cure SMA Awards $90000 to Spinal Muscular Atrophy Researcher SMA News Today ClÃ©ry is a senior researcher in FrÃ©dÃ©ric Allain's laboratory at ETH Zurich that specializes in the structure determination of protein-RNA complexes using NMR (nuclear magnetic resonance). SMA is triggered by an SMN1 gene mutation â?? the gene that ... Cure SMA Awards $90000 to Spinal Muscular Atrophy Researcher - SMA News...	nmrlearner	Online News	0	04-06-2016 07:18 AM
Wait in science can be longer than in sport: Nobel laureate - Times of India <img alt="" height="1" width="1" /> Wait in science can be longer than in sport: Nobel laureate Times of India It was for developing nuclear magnetic resonance (NMR) as a tool to find 3-D structures of proteins that Wuthrich was awarded the Nobel Prize. He said that it was important to know the three-dimensional structure of proteins to understand how different ... and more » Wait in science can be longer than in sport: Nobel laureate - Times of India More...	nmrlearner	Online News	0	01-18-2014 11:31 AM
How Crowdfunding Could Help Cure Rare Diseases How Crowdfunding Could Help Cure Rare Diseases The Rare Genomics Institute is using a crowdfunding model to help treat the nearly 7,000 rare diseases that exist in the U.S. More...	nmrlearner	General	0	02-29-2012 10:32 PM
Structure of key protein associated with Parkinson's disease determined - Science Codex <img alt="" height="1" width="1" /> Structure of key protein associated with Parkinson's disease determined Science Codex Pochapsky's lab was responsible for examining the protein using nuclear magnetic resonance, a sort of MRI for molecules, housed at the Landsman Research Facility. Alpha-synuclein is found in large quantities in the brain. ... and more » Structure of key protein associated with Parkinson's disease determined - Science Codex More...	nmrlearner	Online News	0	10-24-2011 11:06 PM
[NMR paper] Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross- Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross-saturation. Related Articles Precise epitope mapping of malaria parasite inhibitory antibodies by TROSY NMR cross-saturation. Biochemistry. 2005 Jan 18;44(2):518-23 Authors: Morgan WD, Frenkiel TA, Lock MJ, Grainger M, Holder AA We have applied NMR cross-saturation with TROSY detection to the problem of precisely mapping conformational epitopes on complete protein antigen molecules. We have investigated complexes of the Fab fragments of two antibodies that...	nmrlearner	Journal club	0	11-24-2010 11:14 PM
[NMR paper] Structure of a malaria parasite antigenic determinant displayed on filamentous bacter Structure of a malaria parasite antigenic determinant displayed on filamentous bacteriophage determined by NMR spectroscopy: implications for the structure of continuous peptide epitopes of proteins. Related Articles Structure of a malaria parasite antigenic determinant displayed on filamentous bacteriophage determined by NMR spectroscopy: implications for the structure of continuous peptide epitopes of proteins. Protein Sci. 2001 Jun;10(6):1150-9 Authors: Monette M, Opella SJ, Greenwood J, Willis AE, Perham RN The NANP repeating sequence of...	nmrlearner	Journal club	0	11-19-2010 08:32 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off