Scripps Uncovers Structure of Key Protein Receptor for Medications - Times of San Diego
Scripps Uncovers Structure of Key Protein Receptor for Medications - Times of San Diego
Times of San Diego Scripps Uncovers Structure of Key Protein Receptor for Medications Times of San Diego
Matthew Eddy and Kurt Wüthrich Study leaders Matthew Eddy (left) and Nobel laureate Kurt Wüthrich with their imaging equipment. Photo by Madeline McCurry-Schmidt for Scripps Research Institute. A study led by the Scripps Research Institute uncovered ...
San Diego Scientists Uncover Structure Of Key Proteins Targeted By Half Of Medications - KPBS
San Diego Scientists Uncover Structure Of Key Proteins Targeted By Half Of Medications - KPBS
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San Diego Scientists Uncover Structure Of Key Proteins Targeted By Half Of Medications
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A study led by The Scripps Research Institute uncovered more details about the structure of key proteins targeted by nearly half of medications, which could help with future drug development, the La Jolla-based organization reported...
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[NMR paper] NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
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PTEN, an important tumor suppressor and a key regulator of the PI3K/AKT signaling pathway, is often deleted/mutated in different types of cancer. The E3 ubiquitin ligase NEDD4-1 catalyzes the polyubiquitination of PTEN, thereby acting as a negative...
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[NMR paper] Dual screening of BPTF and Brd4 using protein-observed fluorine NMR uncovers new bromodomain probe molecules.
Dual screening of BPTF and Brd4 using protein-observed fluorine NMR uncovers new bromodomain probe molecules.
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Abstract
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selec-tive inhibition of bromodomain function is a newly...
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Structure from Disorder: Scripps Research Institute Scientists Find New Source ... - HealthCanal.com
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Structure from Disorder: Scripps Research Institute Scientists Find New Source ...
HealthCanal.com
Wright's laboratory and others have been studying these interactions using a technique called nuclear magnetic resonance (NMR) spectroscopy. However, E1A's intrinsic stickiness means that it tends to aggregate at NMR-friendly concentrations, rendering ...
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Structure from Disorder: Scripps Research Institute Scientists Find New Source ... - HealthCanal.com
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3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org
3D structure of an unmodified G protein-coupled receptor in its natural habitat - Phys.Org
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3D structure of an unmodified G protein-coupled receptor in its natural habitat
Phys.Org
Using NMR spectroscopy, the team mapped the arrangement of atoms in a protein called CXCR1, which detects the inflammatory signal interleukin 8 and, through a G protein located inside the cell, triggers a cascade of events that can mobilize immune ...
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[NMR paper] NMR structure of a receptor-bound G-protein peptide.
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Heterotrimeric GTP-binding proteins (G proteins) regulate cellular activity by coupling to hormone or sensory receptors. Stimulated receptors catalyse the release of GDP from G protein...
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Interleukin-1 (IL-1) proteins, such as IL-1 beta, play a key role in immune and inflammatory responses....
Scripps Uncovers Structure of Key Protein Receptor for Medications - Times of San Diego
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