Scientists Observe Structure of Protein That Plays Major Role in Huntington's Disease, Opening Door to Finding Cause ... - Huntington's Disease News

		BioNMR > NMR community > Online News
Scientists Observe Structure of Protein That Plays Major Role in Huntington's Disease, Opening Door to Finding Cause ... - Huntington's Disease News

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

02-10-2016, 09:28 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,733

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Scientists Observe Structure of Protein That Plays Major Role in Huntington's Disease, Opening Door to Finding Cause ... - Huntington's Disease News

Scientists Observe Structure of Protein That Plays Major Role in Huntington's Disease, Opening Door to Finding Cause ... - Huntington's Disease News

Huntington's Disease News

Scientists Observe Structure of Protein That Plays Major Role in Huntington's Disease, Opening Door to Finding Cause ...
Huntington's Disease News
Leibniz-Institut fÃ¼r Molekulare Pharmakologie (FMP) researchers used a combination of nuclear magnetic resonance spectroscopy (NMR) and electron paramagnetic resonance spectroscopy (EPR), to determine the structure and visualize the protein in both ...

Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms - Huntington's Disease News <img alt="" height="1" width="1"> Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms Huntington's Disease News Researchers at the University of Pittsburgh School of Medicine used advanced nuclear magnetic resonance spectroscopy to directly assess and characterize huntingtin fibrils and other polyglutamine aggregates. Results showed that, unlike what previous ... Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms - Huntington's Disease News More...	nmrlearner	Online News	0	02-06-2016 03:05 AM
Study finding could shed light on molecular mechanisms underlying Huntington's disease - News-Medical.net http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcQ4bPSiC2GxHh2tSrBv-yw0PP4aV7KUqSJA__VTst6Y-abi8OKMJ34YPc5XvnrcWZZ7f9dPIKE Science World Report <img alt="" height="1" width="1"> Study finding could shed light on molecular mechanisms underlying Huntington's disease News-Medical.net ... the process," he said. "Using advanced nuclear magnetic resonance spectroscopy, we were able to provide an unprecedented view of the internal structure of the protein clumps that form in the disease, which we hope will one day lead to new therapies ... Researchers Describe Brain Plaques Involved In...	nmrlearner	Online News	0	02-04-2016 11:46 AM
Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... - EurekAlert (press release) <img alt="" height="1" width="1"> Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... EurekAlert (press release) "Using advanced nuclear magnetic resonance spectroscopy, we were able to provide an unprecedented view of the internal structure of the protein clumps that form in the disease, which we hope will one day lead to new therapies." The gene associated with ... and more » Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... - EurekAlert (press...	nmrlearner	Online News	0	02-03-2016 10:22 PM
How does the 'kissing disease' replicate itself? - Medical News Today <img alt="" height="1" width="1" /> How does the 'kissing disease' replicate itself? Medical News Today To investigate further, he and his team used innovative nuclear magnetic resonance (NMR) techniques to study how the EBNA2 protein of EBV binds to a protein of the TFIIH complex, which helps regulate a protein called RNA polymerase II. RNA polymerase ... and more » How does the 'kissing disease' replicate itself? - Medical News Today More...	nmrlearner	Online News	0	04-11-2014 02:51 PM
Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease - News-Medical.net Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease - News-Medical.net <img alt="" height="1" width="1" /> Prion proteins responsible for Mad cow disease, Creutzfeld-Jakob disease News-Medical.net Kai Schlepckow and Harald Schwalbe at the Goethe University Frankfurt am Main have successfully used time-resolved NMR spectroscopic studies to follow what is happening to every individual amino acid as the prion protein molecules aggregateâ??an ... Read here	nmrlearner	Online News	0	08-16-2013 08:36 PM
[NMR paper] Natural compounds against Alzheimer's disease: molecular recognition of A?1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR. Natural compounds against Alzheimer's disease: molecular recognition of A?1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Natural compounds against Alzheimer's disease: molecular recognition of A?1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR. Chem Asian J. 2013 Mar;8(3):596-602 ...	nmrlearner	Journal club	0	08-01-2013 12:56 PM
Cell contents may be key to controlling toxicity of Huntington's protein - R & D Magazine Cell contents may be key to controlling toxicity of Huntington's protein - R & D Magazine <img alt="" height="1" width="1" /> Cell contents may be key to controlling toxicity of Huntington's protein R & D Magazine ... suggests that the toxic effects of the huntingtin protein on cells may not be driven ... of a new 0.75-mm solid state nuclear magnetic resonance (NMR) probe. Read here	nmrlearner	Online News	0	06-13-2012 11:34 AM
[NMR tweet] NMR for celiac disease: metabonomic insights: A nuclear magnetic resonance spectroscopic approach to the disease... http://bit.ly/ffTXaC NMR for celiac disease: metabonomic insights: A nuclear magnetic resonance spectroscopic approach to the disease... http://bit.ly/ffTXaC Published by pritihonrao (Priti Honrao) on 2011-01-05T02:32:56Z Source: Twitter	nmrlearner	Twitter NMR	0	01-05-2011 02:40 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off