Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules | Scientific Reports - Nature.com
Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules | Scientific Reports - Nature.com
Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules | Scientific Reports - Nature.com
The time-zero HSQC method improves the linear free energy relationship of a polypeptide chain through the accurate measurement of residue-specific equilibrium constants
The time-zero HSQC method improves the linear free energy relationship of a polypeptide chain through the accurate measurement of residue-specific equilibrium constants
Abstract
EXSY (exchange spectroscopy) NMR provides the residue-specific equilibrium constants, K, and residue-specific kinetic rate constants, k, of a polypeptide chain in a two-state exchange in the slow exchange regime. A linear free energy relationship (LFER) discovered in a log k versus log K plot is considered to be a physicochemical basis for smooth folding and conformational...
[NMR paper] Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion
Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion
Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand-receptor complex. In the field of drug design, the recognition that drug efficacy in vivo depends on the lifetime of the drug-protein complex has spawned the concept of designing drugs with particular binding kinetics. To advance this field it is critical to investigate...
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[NMR900 blog] NMR paper in Nature Scientific Reports
NMR paper in Nature Scientific Reports
C.E. Norris, S.A. Quideau, S.M. Landhäusser, G.M. Bernard and R.E. Wasylishen, "Tracking Stable Isotope Enrichment in Tree Seedlings with Solid-State NMR Spectroscopy," Nature Scientific Reports 2 (2012) 719. http://dx.doi.org/10.1038/srep00719https://blogger.googleusercontent.com/tracker/8663203727601106205-993472665316978490?l=nmr900.blogspot.com
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Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules | Scientific Reports - Nature.com
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