Researchers probe brain disease-causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds - Science Daily

		BioNMR > NMR community > Online News
Researchers probe brain disease-causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds - Science Daily

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-06-2019, 06:58 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,776

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Researchers probe brain disease-causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds - Science Daily

Researchers probe brain disease-causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds - Science Daily

Researchers probe brain disease-causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds Science DailyResearchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of ...

Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Atomic-level changes in ALS-linked protein - Science Daily Atomic-level changes in ALS-linked protein - Science Daily Atomic-level changes in ALS-linked protein Science DailyA new study details the minute changes -- down to the level of individual atoms -- that cause a particular protein to form cell-damaging clumps associated with ... Read here	nmrlearner	Online News	0	01-07-2019 05:49 AM
Atomic-level changes in ALS-linked protein - Science Daily Atomic-level changes in ALS-linked protein - Science Daily http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcQeYKSKC6UnNVJRRYMTQlJCypeC2wnzgfQZqoHgkhBTuZ2scCGlwGes0t49hYxuKN0JUy7TUsYB Science Daily <img alt="" height="1" width="1"> Atomic-level changes in ALS-linked protein Science Daily The protein collects in membrane-less organelles, where it may use its low-complexity domain to stick together, much in the way that water collects into droplets on the outside of a cold soda bottle on a humid summer day. Until the publication of this ...	nmrlearner	Online News	0	01-20-2018 10:29 AM
Researchers probe brain disease-causing proteins at the atomic ... - Science Daily Researchers probe brain disease-causing proteins at the atomic ... - Science Daily <img alt="" height="1" width="1"> Researchers probe brain disease-causing proteins at the atomic ... Science Daily Researchers studying a protein that causes a hereditary degenerative brain disease in humans have discovered that the human, mouse and hamster forms of ... and more » Read here	nmrlearner	Online News	0	11-07-2017 07:58 AM
Researchers probe brain disease-causing proteins at the atomic level - Phys.Org Researchers probe brain disease-causing proteins at the atomic level - Phys.Org http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcS-sN8485QvvUQ7Ff6vlVsVUtDn1pu0wAR_CUmuY3TdtC1SeUpFv59P1zO7uMBFSwLRIoFzw0li Phys.Org <img alt="" height="1" width="1"> Researchers probe brain disease-causing proteins at the atomic level Phys.Org Key interresidue contacts and schematic model of the human PrP23-144 amyloid Î²-core. a Small regions of a 900 MHz two-dimensional 13Câ??13C DARR solid-state NMR spectrum recorded with a mixing time of 500 ms for amyloid fibrils generated from ... and...	nmrlearner	Online News	0	11-06-2017 05:23 PM
Atomic-level motion may drive bacteria's ability to evade immune system defenses, finds IU study - IU Newsroom http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcQsf49Oo3cE96BJ2Li7tmOqnyGVNfuWC1eJal9dqZJQ_KO_FZkSl6OIZ9kqcSG7DoM_mzukXdA2 IU Newsroom <img alt="" height="1" width="1"> Atomic-level motion may drive bacteria's ability to evade immune system defenses, finds IU study IU Newsroom Through the use of nuclear magnetic resonance spectroscopy, he and colleagues measured the movement of atoms in CzrA and identified those most affected by zinc. They then "swapped" these atoms out with different amino acids and found that the protein ... and more » Atomic-level motion may drive...	nmrlearner	Online News	0	05-16-2017 10:27 PM
Atomic-level motion may drive bacteria's ability to evade immune system defenses - Science Daily http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcS9ZK4z2mc9CF0y_2jMyBOVdjQWlJM9DDGFDL9m3N2CG2M4S9WkAwPBySBtFr2VU77YRvBjsfQa Science Daily <img alt="" height="1" width="1"> Atomic-level motion may drive bacteria's ability to evade immune system defenses Science Daily Through the use of nuclear magnetic resonance spectroscopy, he and colleagues measured the movement of atoms in CzrA and identified those most affected by zinc. They then "swapped" these atoms out with different amino acids and found that the protein ... and more » Atomic-level motion may drive bacteria's...	nmrlearner	Online News	0	04-22-2017 07:21 AM
Study reveals insights into protein linked to cancer, Alzheimer's disease - Science Daily Study reveals insights into protein linked to cancer, Alzheimer's disease - Science Daily <img alt="" height="1" width="1"> Study reveals insights into protein linked to cancer, Alzheimer's disease Science Daily NMR-based model for Pin1 (â??Aâ?? and â??Bâ?? globular domains), and its interaction with its â??disorderedâ?? protein targets pertinent to cancer and Alzheimer's disease (green). The Pin1 â??Aâ?? and â??Bâ?? domains specialize in peptidyl-prolyl isomerase activity and ... Read here	nmrlearner	Online News	0	06-05-2016 02:18 AM
Study Finds New Moves in Protein's Evolution - Science Daily (press release) <img alt="" height="1" width="1" /> Study Finds New Moves in Protein's Evolution Science Daily (press release) The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ... and more » Study Finds New Moves in Protein's Evolution - Science Daily (press release) More...	nmrlearner	Online News	0	09-30-2013 03:48 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off