Researchers Look at Averting Drug Resistance - Drug Discovery & Development
Researchers Look at Averting Drug Resistance Drug Discovery & Development
Kern and her team studied the protein using nuclear magnetic resonance spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transportingâ??moving the drug from the inside of the cell ...
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Drug Discovery & Development
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3D Proteins: Getting the Big Picture
Drug Discovery & Development
For decades, with funding from the National Science Foundation (NSF), Hinton has used nuclear magnetic resonance (NMR) to look at protein structure and function. But he wanted to find a way to educate and engage students about his discoveries. ...
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Flavonoids are well known to inhibit the function of the multi-drug-resistance (mdr) transporter by interacting with their ATP binding domains. The precise orientation of these molecules inside the ATP binding pocket is still unclear. We applied the saturation transfer...
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The field of NMR spectroscopy has grown beyond expectations from the first historic observation of nuclear magnetic resonance in 1946 by Bloch and Purcell, to the first generation of protein structures 20 years ago, to the present where NMR structures now represent 15 to 20% of those submitted to the Protein Data Bank (PDB). However, the applications of NMR go far...
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In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10-15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein-ligand interactions. These form the basis for its most...
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Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News To
Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News Today (press release)
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Purifying Proteins: Researchers Use NMR To Improve Drug Development
Medical News Today (press release)
From the NMR data, they were able to determine what part and type of the protein the ligands were binding to and how strongly they would bind. ...
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NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
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