Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release)

		BioNMR > NMR community > Online News
Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release)

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

01-19-2018, 03:47 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,715

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release)

Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release)

EurekAlert (press release)

Research reveals atomic-level changes in ALS-linked protein
EurekAlert (press release)
The protein collects in membrane-less organelles, where it may use its low-complexity domain to stick together, much in the way that water collects into droplets on the outside of a cold soda bottle on a humid summer day. Until the publication of this ...

and more »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Discovery puts the brakes on HIV's ability to infect \| EurekAlert ... - EurekAlert (press release) http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSaLLJxZzQZDY1S6ZFCefSOpxqarvP-0dzGgSkA_LSAHhHaIKXvNDA32bngTwOlHiQ7EP_6-9AC EurekAlert (press release) <img alt="" height="1" width="1"> Discovery puts the brakes on HIV's ability to infect \| EurekAlert ... EurekAlert (press release) In a study led by the University of Delaware and the University of Pittsburgh School of Medicine, researchers discovered a 'brake' that interferes with HIV's development into an infectious agent. This mechanism prevents the capsid -- the protein shell ... and more » Discovery puts the brakes...	nmrlearner	Online News	0	12-01-2017 08:23 AM
Atomic-level motion may drive bacteria's ability to evade immune system defenses Indiana University - EurekAlert (press release) http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcQua6i8f-w_dssq0DquUvqjy5IzgyN86xgfQGTv4zVJsgdI861V1sPT9EQddr7PiQtfcf1GCC-3 EurekAlert (press release) <img alt="" height="1" width="1"> Atomic-level motion may drive bacteria's ability to evade immune system defenses Indiana University EurekAlert (press release) Through the use of nuclear magnetic resonance spectroscopy, he and colleagues measured the movement of atoms in CzrA and identified those most affected by zinc. They then "swapped" these atoms out with different amino acids and found that the protein ... and more »...	nmrlearner	Online News	0	04-21-2017 03:35 PM
Evolutionary advantage of the common periwinkle \| EurekAlert ... - EurekAlert (press release) <img alt="" height="1" width="1"> Evolutionary advantage of the common periwinkle \| EurekAlert ... EurekAlert (press release) A special kind of small sulfur-rich proteins, the metallothioneins, have an extraordinarily large capability for binding heavy metals. An international team of ... and more » Evolutionary advantage of the common periwinkle \| EurekAlert ... - EurekAlert (press release) More...	nmrlearner	Online News	0	03-24-2017 10:14 PM
Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... - EurekAlert (press release) http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcSO0MkkUxtPQ4lK58RIiZ3I6PBDLS0IC8TOKFk2eGEQsEQ7UT3TJT4nSpwXD4xz1LnsOr5T6RU5 EurekAlert (press release) <img alt="" height="1" width="1"> Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... EurekAlert (press release) Structural biologists provide a new explanation for how ALS-associated genetic flaws interfere with the proper function and behavior of the protein TDP-43. and more » Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... - EurekAlert (press release)	nmrlearner	Online News	0	08-19-2016 04:05 AM
Alzheimer fibrils at atomic resolution - EurekAlert (press release) <img alt="" height="1" width="1"> Alzheimer fibrils at atomic resolution EurekAlert (press release) Only solid-state nuclear magnetic resonance spectroscopy (solid-state NMR) is capable of offering a view at the atomic level in this case. New developments in methods made it possible to measure a network of distances between the atoms in the protein ... and more » Alzheimer fibrils at atomic resolution - EurekAlert (press release) More...	nmrlearner	Online News	0	08-06-2016 07:22 PM
Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release) Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease - Newswise (press release) <img alt="" height="1" width="1"> Study Reveals Insights Into Protein Linked to Cancer and Alzheimer's Disease Newswise (press release) Yet they are increasingly recognized as functional units, figuring prominently in cancer-related proteins. So a second question has been, how does Pin1 interact with those disordered sites? Using high-field nuclear magnetic resonance (NMR) spectroscopy ... and more » Read here	nmrlearner	Online News	0	06-03-2016 04:52 PM
Public Release: 6-May-2015 Magic spin put on protein to tease out its 1st ... - EurekAlert (press release) Public Release: 6-May-2015 Magic spin put on protein to tease out its 1st ... - EurekAlert (press release) http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcT6bb2xShL8rCe4MjWU6XWHQs-DSrX4qBh_OrgUUBWs7TPY9jMID-zp4ClJoaS2VKgzbsaNxZXu EurekAlert (press release) <img alt="" height="1" width="1"> Public Release: 6-May-2015 Magic spin put on protein to tease out its 1st ... EurekAlert (press release) ... the collaborative group of researchers used a method called Magic Angle Spinning Solid-State NMR Spectroscopy to determine the order in which the components of a protein, called...	nmrlearner	Online News	0	05-07-2015 12:59 AM
Scripps Research scientists find E. coli enzyme must move to function - EurekAlert (press release) <img alt="" height="1" width="1" /> Scripps Research scientists find E. coli enzyme must move to function EurekAlert (press release) For the new study, the scientists turned to an imaging technique known as nuclear magnetic resonance (NMR) spectroscopy, in combination with X-ray crystallography. Unlike X-ray crystallography, a technique used to determine the structure of proteins in ... and more » Scripps Research scientists find E. coli enzyme must move to function - EurekAlert (press release) More...	nmrlearner	Online News	0	04-07-2011 11:40 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off