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GPCR's Internal Dynamics Probed with NMR - Genetic Engineering & Biotechnology News
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GPCR's Internal Dynamics Probed with NMR
Genetic Engineering & Biotechnology News
These scientists used nuclear magnetic resonance (NMR) spectroscopy to capture many different conformations of a GPCR protein called the A2A adenosine receptor (A2AAR). A2AAR, which regulates blood flow and inflammation and mediates the effects of ...
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GPCR's Internal Dynamics Probed with NMR - Genetic Engineering & Biotechnology News
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01-02-2018 04:22 PM
Advanced Image of A2aAR Protein Could Lead to Better Drug ... - Genetic Engineering & Biotechnology News
Advanced Image of A2aAR Protein Could Lead to Better Drug ... - Genetic Engineering & Biotechnology News
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Advanced Image of A2aAR Protein Could Lead to Better Drug ...
Genetic Engineering & Biotechnology News
A Scripps Research Institute (TSRI) team reports that it has found structural features in a key protein used in drug design that may lead to new ways to target diseases. The A2a adenosine receptor...
nmrlearner
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12-29-2017 09:03 PM
For Some Chaperones, Stability Comes in Pairs | GEN - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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For Some Chaperones, Stability Comes in Pairs | GEN
Genetic Engineering & Biotechnology News
Like an acrobatic duoâ??single proteins lend each other greater stability. . Chaperone molecules are an important part of protein dynamics for daily cellular function. Misfolded proteins are nonfunctional and can cause ...
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For Some Chaperones, Stability Comes in Pairs |...
nmrlearner
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12-09-2017 07:49 AM
Frankenstein Proteins Stitched Together by Scientists - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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Frankenstein Proteins Stitched Together by Scientists
Genetic Engineering & Biotechnology News
â??High-resolution structures of the designed proteins CA01 and DA05R1 were solved by x-ray crystallography (2.2 angstrom resolution) and nuclear magnetic resonance, respectively, and there was excellent agreement with the design models.â?? Essentially ...
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nmrlearner
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05-11-2016 08:04 PM
Dissecting the Structure of Membrane Proteins - Genetic Engineering & Biotechnology News
Dissecting the Structure of Membrane Proteins - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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Dissecting the Structure of Membrane Proteins
Genetic Engineering & Biotechnology News
In particular, Dr. Rosenbaum and his laboratory use protein engineering, X-ray crystallography, and NMR spectroscopy to study the structure and dynamics of molecules involved in hormone signaling and lipid...
nmrlearner
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09-30-2015 10:34 PM
More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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More Dynamic Protein Profiling
Genetic Engineering & Biotechnology News
â??As a tool for preventing unnecessary work on the structure determination side, we introduced the 'NMR Profile' for identifying, from among the many proteins that we screen, those that are available as a structure-quality solution and...
nmrlearner
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09-02-2015 05:44 AM
Magazine Preview: More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
Magazine Preview: More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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Magazine Preview: More Dynamic Protein Profiling
Genetic Engineering & Biotechnology News
â??As a tool for preventing unnecessary work on the structure determination side, we introduced the 'NMR Profile' for identifying, from among the many proteins that we screen, those that are available...
nmrlearner
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08-31-2015 09:39 PM
Catching Nanodiscs - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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Catching Nanodiscs
Genetic Engineering & Biotechnology News
Typical methods applied to study proteinâ??glycan interactions are X-ray diffraction, nuclear magnetic resonance, calorimetry, equilibrium dialysis, and enzyme-linked immunosorbent assay. However, limited solubility of glycolipids and low affinities of ...
Catching Nanodiscs - Genetic Engineering & Biotechnology News