Discovery of key protein's structure may help improve drug design - News-Medical.net
Discovery of key protein's structure may help improve drug design - News-Medical.net
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Discovery of key protein's structure may help improve drug design
News-Medical.net
Scientists at The Scripps Research Institute have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases.
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12-30-2017 10:44 AM
Protein motion questions unravelled. - Technology Networks (blog)
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Technology Networks (blog)
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Protein motion questions unravelled.
Technology Networks (blog)
The researchers took starting structural information based on nuclear magnetic resonance or X-ray techniques, and simulated 14 behavioural dynamics in 12 proteins in times ranging from 50 nanoseconds to 1.23 milliseconds. In short, the researchers ...
Protein motion questions unravelled. - Technology Networks (blog)
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10-17-2017 10:19 AM
Protein Motion Questions Unravelled - Technology Networks
http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcQvMIzzqdPI4exiUT4_6rC8MimBHNz4EacVKRw__4dZxiahWmpNauW9gRZNDqGpKBFPylHv8p9d
Technology Networks
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Protein Motion Questions Unravelled
Technology Networks
The researchers took starting structural information based on nuclear magnetic resonance or X-ray techniques, and simulated 14 behavioural dynamics in 12 proteins in times ranging from 50 nanoseconds to 1.23 milliseconds. In short, the researchers ...
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Protein Motion Questions Unravelled - Technology Networks
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10-16-2017 03:30 PM
New Approach for Membrane Protein Crystallization - Technology Networks
New Approach for Membrane Protein Crystallization - Technology Networks
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New Approach for Membrane Protein Crystallization
Technology Networks
Nanodiscs are also widely used to study the structure of membrane proteins using nuclear magnetic resonance (NMR), cryo-electron microscopy, atomic force microscopy, and other methods. Direct use of membrane proteins embedded in nanodiscs for ...
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03-09-2017 12:11 AM
New Approach for Membrane Protein Crystallization - Technology Networks
New Approach for Membrane Protein Crystallization - Technology Networks
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Technology Networks
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New Approach for Membrane Protein Crystallization
Technology Networks
Nanodiscs are also widely used to study the structure of membrane proteins using nuclear magnetic resonance (NMR), cryo-electron microscopy, atomic force microscopy, and other methods. Direct use of membrane proteins embedded in nanodiscs for ...
nmrlearner
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03-08-2017 09:02 AM
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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New Protein Evolution Insight Could Improve Drug Design
Drug Discovery & Development
The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ...
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New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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10-01-2013 09:43 AM
[NMR paper] NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs.
NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs.
J Pept Sci. 2013 Jan;19(1):33-45
Authors: Rawat A, Kumar D
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06-07-2013 10:04 AM
Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Re
Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-ray Crystallography and NMR.
Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-ray Crystallography and NMR.
Future Med Chem. 2010 Sep 1;2(9):1451-1468
Authors: Gay SC, Roberts AG, Halpert JR
Cytochromes P450 (P450s) play a major role in the clearance of drugs, toxins, and environmental pollutants. Additionally, metabolism by P450s can result in toxic or carcinogenic products. The metabolism of...