Protein folding: Much more intricate than we thought Chemical & Engineering News
In 2014, a team led by Kalodimos reported an NMR-based structure of Trigger Factor showing that it binds to an unfolded peptide in at least four spots where the peptide has stretches of six to 10 hydrophobic residues (Science, DOI: 10.1126/science ...
Analyzing the Folding and Binding Steps of an IntrinsicallyDisordered Protein by Protein Engineering
Analyzing the Folding and Binding Steps of an IntrinsicallyDisordered Protein by Protein Engineering
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00350/20170711/images/medium/bi-2017-003503_0007.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00350
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07-12-2017 12:48 AM
More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
More Dynamic Protein Profiling - Genetic Engineering & Biotechnology News
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Genetic Engineering & Biotechnology News
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More Dynamic Protein Profiling
Genetic Engineering & Biotechnology News
â??As a tool for preventing unnecessary work on the structure determination side, we introduced the 'NMR Profile' for identifying, from among the many proteins that we screen, those that are available as a structure-quality solution and...
nmrlearner
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09-02-2015 05:44 AM
The Right Resin Means A Purer Protein - Genetic Engineering News
The Right Resin Means A Purer Protein - Genetic Engineering News
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The Right Resin Means A Purer Protein
Genetic Engineering News
Steven Cramer, Ph.D., a professor of chemical and biological engineering at Rensselaer Polytechnic Institute, is using biophysical tools (NMR, SPR, and AFM), molecular simulations, coarse-grain modeling, and â??a lot of chromatographyâ?? to develop models ...
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nmrlearner
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04-15-2014 11:00 PM
Protein-Specific Discovery Strategies - Genetic Engineering News
Protein-Specific Discovery Strategies - Genetic Engineering News
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Protein-Specific Discovery Strategies
Genetic Engineering News
â??The most challenging aspect is finding ways to express and prepare labeled G-protein-coupled receptors for NMR studies, so that we can learn about the timescales of conformational changes,â?? notes Dr. Kobilka. Structure-function relationship studies ...
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nmrlearner
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03-17-2014 07:23 PM
Targeting Protein-Protein Interactions - Genetic Engineering News
Targeting Protein-Protein Interactions - Genetic Engineering News
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Targeting Protein-Protein Interactions
Genetic Engineering News
Researchers are scheduled to present the cutting edge of their tools and technologies targeting protein-protein interactions (PPIs) at Select Biosciences' upcoming â??Discovery Chemistry Congressâ?? meeting. New tools and approaches aimed at visualization ...
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nmrlearner
Online News
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02-15-2013 05:21 PM
Protein Interactions In Membranes - Chemical & Engineering News
Protein Interactions In Membranes - Chemical & Engineering News
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Chemical & Engineering News
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Protein Interactions In Membranes
Chemical & Engineering News
When researchers use NMR to study protein-complex formation in cell-membrane mimics called micelles, they run the risk of misinterpreting shifts in the spectra. For instance, protein A and protein B might just appear to be associating because the ...
nmrlearner
Online News
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11-29-2011 04:49 AM
Proteins Reveal Their Secrets Under Pressure - Chemical & Engineering News
Proteins Reveal Their Secrets Under Pressure - Chemical & Engineering News
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Chemical & Engineering News
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Proteins Reveal Their Secrets Under Pressure
Chemical & Engineering News
With the device, the researchers attempted an NMR experiment they call pressure perturbation transient state spectroscopy. The experiment begins with a pressure spike that unfolds a protein in solution in an NMR sample tube; then the protein refolds ...
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08-02-2011 12:25 AM
Elevating Oxygen - Chemical & Engineering News
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Elevating Oxygen
Chemical & Engineering News
Oxygen is the ugly duckling of biomolecular nuclear magnetic resonance. Although it is a key atom in proteins and nucleic acids, its siblings carbon, ...
Elevating Oxygen - Chemical & Engineering News
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