[NMR paper] NMR Experiments Shed New Light on Glycan Recognition by Human and Murine Norovirus Capsid Proteins
NMR Experiments Shed New Light on Glycan Recognition by Human and Murine Norovirus Capsid Proteins
Glycan-protein interactions are highly specific yet transient, rendering glycans ideal recognition signals in a variety of biological processes. In human norovirus (HuNoV) infection, histo-blood group antigens (HBGAs) play an essential but poorly understood role. For murine norovirus infection (MNV), sialylated glycolipids or glycoproteins appear to be important. It has also been suggested that HuNoV capsid proteins bind to sialylated ganglioside head groups. Here, we study the binding of...
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[NMR paper] Automated glycan assembly of 19F labelled glycan probes enables high-throughput NMR studies of protein-glycan interactions
Automated glycan assembly of 19F labelled glycan probes enables high-throughput NMR studies of protein-glycan interactions
Protein-glycan interactions mediate important biological processes, including pathogen host invasion and cellular communication. Major challenges to monitoring these low affinity interactions are the required high sensitivity of a biophysical assay and to cover a breath of synthetic well-defined structures. Here, we showcase an expedite approach that integrates automated glycan assembly (AGA) of 19 F labelled probes and high-throughput NMR methods, enabling the study...
[ASAP] Post-Translational Modifications in Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2
Post-Translational Modifications in Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00256/20180613/images/medium/bi-2018-00256v_0007.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00256
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
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06-14-2018 08:12 AM
[NMR paper] A rigid lanthanide binding tag to aid NMR studies of a 70 kDa homodimeric coat protein of human norovirus.
A rigid lanthanide binding tag to aid NMR studies of a 70 kDa homodimeric coat protein of human norovirus.
Related Articles A rigid lanthanide binding tag to aid NMR studies of a 70 kDa homodimeric coat protein of human norovirus.
Chem Commun (Camb). 2015 Nov 10;
Authors: Mallagaray A, Domínguez G, Peters T, Pérez-Castells J
Abstract
Attachment of human noroviruses to histo blood group antigens is thought to be essential for infection of host cells. Molecular details of the attachment process can be studied in vitro using a...
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11-11-2015 02:40 PM
Postdoctoral Fellow - Post-translational modification, NMR : Duarte ...
Postdoctoral Fellow - Post-translational modification, NMR : Duarte ...
Postdoctoral Fellow - Post-translational modification, NMR, Duarte, United States. View all science jobs and scientific careers from Nature Jobs, the premier ...
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[NMR paper] Heteronuclear NMR studies of the specificity of the post-translational modification o
Heteronuclear NMR studies of the specificity of the post-translational modification of biotinyl domains by biotinyl protein ligase.
Related Articles Heteronuclear NMR studies of the specificity of the post-translational modification of biotinyl domains by biotinyl protein ligase.
FEBS Lett. 2000 Aug 18;479(3):93-8
Authors: Reche PA, Howard MJ, Broadhurst RW, Perham RN
The lipoyl domains of 2-oxo acid dehydrogenase multienzyme complexes and the biotinyl domains of biotin-dependent enzymes have homologous structures, but the target lysine...
A post-translational modification of human Norovirus capsid protein attenuates glycan binding - Nature.com
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