Novel functional insight in protein complex, possible new target for antibiotics - Phys.org

		BioNMR > NMR community > Online News
Novel functional insight in protein complex, possible new target for antibiotics - Phys.org

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

01-07-2019, 05:49 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Novel functional insight in protein complex, possible new target for antibiotics - Phys.org

Novel functional insight in protein complex, possible new target for antibiotics - Phys.org

Novel functional insight in protein complex, possible new target for antibiotics Phys.orgResearchers at Utrecht University have gained new insights into the structure and function of a protein complex that maintains the outer membrane of a bacteria.

Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Biochemists simulate a protein-folding chaperone's functional dance - Phys.Org Biochemists simulate a protein-folding chaperone's functional dance - Phys.Org http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcQEGcDQsqzIL51LSYVBf-L0j8Nukf3cJBRqJeaJhiwwYPy31nISXJG844HnHmO_Jq9dOKChgpfH Phys.Org <img alt="" height="1" width="1"> Biochemists simulate a protein-folding chaperone's functional dance Phys.Org A recent advance in understanding of the role of an interdomain linker in Hsp70 chaperones by Gierasch's group at UMass Amherst required clever computational techniques, massive computing power and masterful use of NMR, she says. Credit: UMass ... and more...	nmrlearner	Online News	0	08-29-2017 05:35 PM
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00179/20170426/images/medium/bi-2017-00179h_0005.gif Biochemistry DOI: 10.1021/acs.biochem.7b00179 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/juO1BIhAbrk More...	nmrlearner	Journal club	0	04-27-2017 04:02 AM
Mitosis study finds potential cancer target - Phys.Org http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcQOSQOymwfZxoOGZbSEtUSw4MVRDTEkuNdr_LNYBhV4oAIRXjpXv9AnzxSNAbK8tQfDFa9VkAUR Phys.Org <img alt="" height="1" width="1"> Mitosis study finds potential cancer target Phys.Org Kumar and Page led the effort by using nuclear magnetic resonance and x-ray crystallography that resolved the proteins and their interactions down to the scale of individual atomsâ??1.3 tenths of billionths of a meter. What he and the team found was ... and more » Mitosis study finds potential cancer target - Phys.Org	nmrlearner	Online News	0	08-31-2016 02:34 PM
Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcQxtycuknWdkaObftplW7gQ2IpeTrxE7FEQhr1Oxm8bGHeDqpul1hUHa4pGZSHUHhsvbnExYhJy Phys.Org <img alt="" height="1" width="1"> Early progress reported in designing drugs that target 'disordered' proteins Phys.Org The p27 protein works by binding to an enzyme and forming a complex that blocks cell division. This type of regulation is necessary to keep cells in check when not otherwise instructed to divide. In this study St. Jude researchers used NMR...	nmrlearner	Online News	0	12-01-2015 11:22 PM
New insight on HIV life cycle gained through creative use of high-energy X-rays - Phys.Org <img alt="" height="1" width="1" /> New insight on HIV life cycle gained through creative use of high-energy X-rays Phys.Org The structural basis of the recognition between RRE and Rev-protein remained elusive for many years because of the difficulties in the structural determination for the RRE RNA. Crystallography and nuclear magnetic resonance spectroscopy (NMR) are often ... New insight on HIV life cycle gained through creative use of high-energy X-rays - Phys.Org More...	nmrlearner	Online News	0	05-13-2014 03:11 PM
[NMR paper] Study of ion translocation by respiratory complex I. A new insight using (23)Na NMR spectroscopy. Study of ion translocation by respiratory complex I. A new insight using (23)Na NMR spectroscopy. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Study of ion translocation by respiratory complex I. A new insight using (23)Na NMR spectroscopy. Biochim Biophys Acta. 2012 Oct;1817(10):1810-6 Authors: Batista AP, Marreiros BC, Louro RO, Pereira MM Abstract The research on complex I has gained recently a new enthusiasm, especially after the resolution...	nmrlearner	Journal club	0	05-04-2013 09:18 PM
[NMR paper] Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. Biochim Biophys Acta. 2013 Feb;1828(2):595-601 Authors: Zhang J, Qu X, Covarrubias M,...	nmrlearner	Journal club	0	04-05-2013 10:53 AM
[NMR paper] Structural and Functional Insight into ADF/Cofilin from Trypanosoma brucei. Structural and Functional Insight into ADF/Cofilin from Trypanosoma brucei. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Structural and Functional Insight into ADF/Cofilin from Trypanosoma brucei. PLoS One. 2013;8(1):e53639 Authors: Dai K, Liao S, Zhang J, Zhang X, Tu X Abstract The ADF/cofilin family has been characterized as a group of actin-binding...	nmrlearner	Journal club	0	02-03-2013 10:19 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off