The recent melamine crisis in China has pointed out a serious deficiency in current food control systems, namely, they specifically focus on selected known compounds. This targeted approach allowed the presence of melamine in milk products to be overlooked for a considerable time. To avoid this in the future, nontargeted NMR screening is proposed.
[Stan NMR blog] RF and EMF screening materials
RF and EMF screening materials
A Chinese Company produces high-tech materials for EMI screening
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02-13-2011 08:54 PM
[NMR paper] Screening of protein kinases by ATP-STD NMR spectroscopy.
Screening of protein kinases by ATP-STD NMR spectroscopy.
Related Articles Screening of protein kinases by ATP-STD NMR spectroscopy.
J Am Chem Soc. 2005 Jun 8;127(22):7978-9
Authors: McCoy MA, Senior MM, Wyss DF
ATP-STD NMR takes advantage of Mg2+ binding to ATP to adjust the ATP affinity for protein kinases permitting a wide range of Ki's to be determined for ATP competitive ligands. Substituting Mn2+ for Mg2+ creates a paramagnetic probe (MnATP) from which the proximity of non-ATP competitive ligands can be inferred. Internal standards and...
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11-25-2010 08:21 PM
[NMR paper] Application of NMR SHAPES screening to an RNA target.
Application of NMR SHAPES screening to an RNA target.
Related Articles Application of NMR SHAPES screening to an RNA target.
J Am Chem Soc. 2003 Dec 24;125(51):15724-5
Authors: Johnson EC, Feher VA, Peng JW, Moore JM, Williamson JR
Several NMR screening techniques have been developed in recent years to aid in the identification of lead drug compounds. These NMR methods have traditionally been used for protein targets, and here we examine their applicability for an RNA target. We used the SHAPES compound library to test three different NMR...
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[NMR paper] Second-site NMR screening and linker design.
Second-site NMR screening and linker design.
Related Articles Second-site NMR screening and linker design.
Curr Top Med Chem. 2003;3(1):69-80
Authors: Jahnke W, Flörsheimer A, Blommers MJ, Paris CG, Heim J, Nalin CM, Perez LB
One of the prime merits of NMR as a tool for lead finding in drug discovery research is its sensitivity and robustness to detect weak protein-ligand interactions. This sensitivity allows to build up ligands for a given target in a modular way, by a fragment-based approach. In this approach, two ligands are seperately...
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[NMR paper] Integration of NMR and high-throughput screening.
Integration of NMR and high-throughput screening.
Related Articles Integration of NMR and high-throughput screening.
Comb Chem High Throughput Screen. 2002 Dec;5(8):613-21
Authors: Hajduk PJ, Burns DJ
NMR-based screening has become a powerful method for the identification and analysis of low-molecular weight organic compounds that bind to protein targets and can be utilized in drug discovery programs. In particular, heteronuclear NMR-based screening can yield information about both the affinity and binding location of potential lead compounds....
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[NMR paper] Screening mixtures for biological activity by NMR.
Screening mixtures for biological activity by NMR.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif Related Articles Screening mixtures for biological activity by NMR.
Eur J Biochem. 1997 Jun 15;246(3):705-9
Authors: Meyer B, Weimar T, Peters T
Development of the new drugs often involves the screening of compound libraries for biological activity. Currently, the biologically active component can only be identified if either a pure compound is being...
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[Stan NMR blog] RF and EMF screening materials
RF and EMF screening materials
A Chinese Company produces high-tech materials for EMI screening.
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08-21-2010 05:42 PM
[NMR paper] NMR screening in drug discovery.
NMR screening in drug discovery.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR screening in drug discovery.
Curr Opin Biotechnol. 1999 Feb;10(1):54-8
Authors: Moore JM
NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...
NMR for Nontargeted Screening of Melamine in Baby Foods
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