[NMR paper] NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions
NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions
A survey, primarily based on work in the authors' laboratory during the last 10 years, is provided of recent developments in NMR studies of exchange processes involving protein-ligand and protein-protein interactions. We start with a brief overview of the theoretical background of Dark state Exchange Saturation Transfer (DEST) and lifetime line-broadening (?R(2)) NMR methodology. Some limitations of the DEST/?R(2) methodology in applications to molecular systems with intermediate molecular...
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03-18-2022 12:01 AM
[NMR paper] Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Related Articles Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Angew Chem Int Ed Engl. 2014 Sep 4;
Authors: Buratto R, Mammoli D, Chiarparin E, Williams G, Bodenhausen G
Abstract
Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long-lived states (LLS) in NMR...
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09-10-2014 11:24 AM
[NMR paper] (19) F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY-Domain Containing SOCS Box Protein 2.
(19) F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY-Domain Containing SOCS Box Protein 2.
(19) F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY-Domain Containing SOCS Box Protein 2.
Chem Biol Drug Des. 2014 May 9;
Authors: Leung EW, Yagi H, Harjani JR, Mulcair MD, Scanlon MJ, Baell JB, Norton RS
Abstract
SPRY domain-containing SOCS box protein 2 (SPSB2) regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation. Inhibiting this interaction...
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Research and Markets: Protein-Ligand Interactions. Methods and Principles in ... - Business Wire (press release)
Research and Markets: Protein-Ligand Interactions. Methods and Principles in ... - Business Wire (press release)
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Research and Markets: Protein-Ligand Interactions. Methods and Principles in ...
Business Wire (press release)
The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating ...
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08-29-2012 04:31 PM
Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions.
Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions.
Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions.
BMC Struct Biol. 2011 May 12;11(1):24
Authors: Isvoran A, Badel A, Craescu CT, Miron S, Miteva MA
ABSTRACT: BACKGROUND: Disrupting protein-protein interactions by small organic molecules is nowadays a promising strategy employed to block protein targets involved in different pathologies. However, structural...
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05-17-2011 06:21 PM
[NMR paper] Probing the binding entropy of ligand-protein interactions by NMR.
Probing the binding entropy of ligand-protein interactions by NMR.
Related Articles Probing the binding entropy of ligand-protein interactions by NMR.
Chembiochem. 2005 Sep;6(9):1585-91
Authors: Homans SW
NMR methods for exploring 'dark' states in ligand binding and protein-protein interactions - ScienceDirect.com
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