[ASAP] NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
Robert Creutznacher, Thorben Maass, Barbora Veselkova, George Ssebyatika, Thomas Krey, Martin Empting, Norbert Tautz, Martin Frank, Knut Ko?lbel, Charlotte Uetrecht, and Thomas Peters
https://pubs.acs.org/cms/10.1021/jacs.2c05603/asset/images/medium/ja2c05603_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.2c05603
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07-16-2022 01:22 AM
[NMR paper] NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain
We have used chemical shift perturbation (CSP) and saturation transfer difference (STD) NMR experiments to identify and characterize the binding of selected ligands to the receptor-binding domain (RBD) of the spike glycoprotein (S-protein) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We also subjected full-length S-protein to STD NMR experiments, allowing correlations with RBD-based results. CSPs reveal the binding sites for heparin and fondaparinux, and...
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07-16-2022 01:22 AM
[NMR paper] (15)N NMR studies provide insights into physico-chemical properties of room-temperature ionic liquids
(15)N NMR studies provide insights into physico-chemical properties of room-temperature ionic liquids
Ionic liquids (ILs) have gained a lot of attention as alternative solvents in many fields of science in the last two decades. It is known that the type of anion has a significant influence on the macroscopic properties of the IL. To gain insights into the molecular mechanisms responsible for these effects it is important to characterize these systems at the microscopic level. Such information can be obtained from nuclear spin-relaxation studies which for compounds with natural isotope...
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05-24-2021 11:59 PM
[NMR paper] Insights into Structures and Dynamics of Flavivirus Proteases from NMR Studies.
Insights into Structures and Dynamics of Flavivirus Proteases from NMR Studies.
Related Articles Insights into Structures and Dynamics of Flavivirus Proteases from NMR Studies.
Int J Mol Sci. 2020 Apr 05;21(7):
Authors: Li Q, Kang C
Abstract
Nuclear magnetic resonance (NMR) spectroscopy plays important roles in structural biology and drug discovery, as it is a powerful tool to understand protein structures, dynamics, and ligand binding under physiological conditions. The protease of flaviviruses is an attractive target for...
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04-09-2020 07:27 PM
[NMR paper] Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Timescales in an Archetypal Proton Channel - Insights from Solid-State NMR.
Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Timescales in an Archetypal Proton Channel - Insights from Solid-State NMR.
Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Timescales in an Archetypal Proton Channel - Insights from Solid-State NMR.
J Am Chem Soc. 2018 Jan 05;:
Authors: Mandala V, Gelenter MD, Hong M
Abstract
The influenza M2 protein forms a tetrameric proton channel that conducts protons from the acidic endosome into the virion by shuttling...
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01-06-2018 11:17 AM
numares Initiates Worldwide Commercial Launch of insightLPâ?˘-S50 to Provide New Insights in Lipoprotein Research - Yahoo Finance
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numares Initiates Worldwide Commercial Launch of insightLPâ?˘-S50 to Provide New Insights in Lipoprotein Research
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numares is an established developer and supplier of innovative high-throughput testing methods for medical diagnostics and biomedical research with expertise in the nuclear magnetic resonance (NMR) spectroscopic analysis of lipoproteins. Lipoproteins ...
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numares Initiates Worldwide Commercial Launch of insightLPâ?˘-S50 to Provide New Insights in Lipoprotein Research - Yahoo Finance
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02-07-2017 04:18 PM
[NMR paper] (19)F-Modified Proteins and (19)F-Containing Ligands as Tools in Solution NMR Studies of Protein Interactions.
(19)F-Modified Proteins and (19)F-Containing Ligands as Tools in Solution NMR Studies of Protein Interactions.
Related Articles (19)F-Modified Proteins and (19)F-Containing Ligands as Tools in Solution NMR Studies of Protein Interactions.
Methods Enzymol. 2015;565:67-95
Authors: Sharaf NG, Gronenborn AM
Abstract
(19)F solution NMR is a powerful and versatile tool to study protein structure and protein-ligand interactions due to the favorable NMR characteristics of the (19)F atom, its absence in naturally occurring...
New Tools Provide New Insights in NMR Studies of Protein Dynamics - Science
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