New structure of key protein holds clues for better drug design - Science Daily

		BioNMR > NMR community > Online News
New structure of key protein holds clues for better drug design - Science Daily

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

12-29-2017, 02:19 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,714

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

New structure of key protein holds clues for better drug design - Science Daily

New structure of key protein holds clues for better drug design - Science Daily

Science Daily

New structure of key protein holds clues for better drug design
Science Daily
To solve this problem, the researchers used a technique called nuclear magnetic resonance (NMR) spectroscopy, which creates strong magnetic fields to locate the positions of probes in a sample. Wthrich is a leader in the NMR field and won the Nobel ...

and more »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
New structure of key protein holds clues for better drug design - Phys.Org http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcS9z-dzqrK5EKA_IqiptaRkf-YiwvL7C53uc9klWLvJAQvZPgvSIJWZ1g-KofljNHDGnCgHT5cA Phys.Org <img alt="" height="1" width="1"> New structure of key protein holds clues for better drug design Phys.Org To solve this problem, the researchers used a technique called nuclear magnetic resonance (NMR) spectroscopy, which creates strong magnetic fields to locate the positions of probes in a sample. Wthrich is a world-renowned leader in the NMR field and ... and more » New structure of key protein holds clues for better drug design -...	nmrlearner	Online News	0	12-29-2017 02:19 AM
Probing a mosquito protein for clues in the fight against Zika - Science Daily <img alt="" height="1" width="1"> Probing a mosquito protein for clues in the fight against Zika Science Daily Using solution nuclear magnetic resonance, a technique that yields molecular-level information about proteins, the researchers were able to describe the 3-D structure and dynamics of a SCP2 variant. The new insights could help scientists screen ... and more » Probing a mosquito protein for clues in the fight against Zika - Science Daily More...	nmrlearner	Online News	0	09-25-2016 05:41 PM
Structure of Bacterial Nanowire Protein Hints at Secrets of Conduction - Science Daily (press release) Structure of Bacterial Nanowire Protein Hints at Secrets of Conduction - Science Daily (press release) <img alt="" height="1" width="1" /> Structure of Bacterial Nanowire Protein Hints at Secrets of Conduction Science Daily (press release) But the protein by itself isn't enough to reveal how conduction works. Many pilin proteins work together to form a fiber, and Reardon and Mueller only had one. Nor did the researchers have the whole fiber to put into the NMR instrument. To get more ... Read here	nmrlearner	Online News	0	11-15-2013 12:34 AM
New Tool for Studying Membrane Protein Structure - Science Daily (press release) New Tool for Studying Membrane Protein Structure - Science Daily (press release) <img alt="" height="1" width="1" /> New Tool for Studying Membrane Protein Structure Science Daily (press release) The team used Overhauser dynamic nuclear polarization enhanced nuclear magnetic resonance (NMR), a technique they developed over the last few years. Using a small and stable radical with an even higher magnetic property than the hydrogen atom of ... Read here	nmrlearner	Online News	0	10-03-2013 02:41 AM
New Tool for Studying Membrane Protein Structure - Science Daily (press release) <img alt="" height="1" width="1" /> New Tool for Studying Membrane Protein Structure Science Daily (press release) The team used Overhauser dynamic nuclear polarization enhanced nuclear magnetic resonance (NMR), a technique they developed over the last few years. Using a small and stable radical with an even higher magnetic property than the hydrogen atom of ... and more » New Tool for Studying Membrane Protein Structure - Science Daily (press release) More...	nmrlearner	Online News	0	10-01-2013 11:15 PM
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development <img alt="" height="1" width="1" /> New Protein Evolution Insight Could Improve Drug Design Drug Discovery & Development The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ... and more » New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development More...	nmrlearner	Online News	0	10-01-2013 09:43 AM
Speeding up drug discovery with rapid 3-D mapping of proteins - Science Daily (press release) Speeding up drug discovery with rapid 3-D mapping of proteins - Science Daily (press release) <img alt="" height="1" width="1" /> Speeding up drug discovery with rapid 3-D mapping of proteins Science Daily (press release) Facile backbone structure determination of human membrane proteins by NMR spectroscopy. Nature Methods, 2012; DOI: 10.1038/nmeth.2033. Need to cite ... and more » Read here	nmrlearner	Online News	0	06-13-2012 11:34 AM
NMR and protein structure in drug design: application to cyclotides and conotoxins. NMR and protein structure in drug design: application to cyclotides and conotoxins. NMR and protein structure in drug design: application to cyclotides and conotoxins. Eur Biophys J. 2011 Feb 3; Authors: Daly NL, Rosengren KJ, Troeira Henriques S, Craik DJ Nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for determining the structures, dynamics and interactions of molecules, and the derived information can be useful in drug design applications. This article gives a brief overview of the role of NMR in drug design and...	nmrlearner	Journal club	0	02-04-2011 11:34 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off