A new mechanism of toxicity in Alzheimer's disease revealed by the 3D structure of A? protein - EurekAlert

		BioNMR > NMR community > Online News
A new mechanism of toxicity in Alzheimer's disease revealed by the 3D structure of A? protein - EurekAlert

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

06-27-2020, 01:58 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

A new mechanism of toxicity in Alzheimer's disease revealed by the 3D structure of A? protein - EurekAlert

A new mechanism of toxicity in Alzheimer's disease revealed by the 3D structure of A? protein - EurekAlert

A new mechanism of toxicity in Alzheimer's disease revealed by the 3D structure of A? protein EurekAlert Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search EurekAlert Read here	nmrlearner	Online News	0	06-22-2020 10:19 PM
Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search EurekAlert Read here	nmrlearner	Online News	0	06-16-2020 01:36 AM
New interaction mechanism of proteins discovered \| EurekAlert ... - EurekAlert (press release) <img alt="" height="1" width="1"> New interaction mechanism of proteins discovered \| EurekAlert ... EurekAlert (press release) UZH researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite ... and more » New interaction mechanism of proteins discovered \| EurekAlert ... - EurekAlert (press release) More...	nmrlearner	Online News	0	02-22-2018 02:13 AM
Alzheimer's Tau protein forms toxic complexes with cell membranes - EurekAlert (press release) Alzheimer's Tau protein forms toxic complexes with cell membranes - EurekAlert (press release) <img alt="" height="1" width="1"> Alzheimer's Tau protein forms toxic complexes with cell membranes EurekAlert (press release) In collaboration with Professor David Eliezer at Weill Cornell School of Medical Sciences in New York, the researchers used Nuclear Magnetic Resonance (NMR) to gain insight into the structure of Tau in the core of the complexes. This revealed that the ... and more » Read here	nmrlearner	Online News	0	12-15-2017 07:54 AM
Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... - EurekAlert (press release) <img alt="" height="1" width="1"> Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... EurekAlert (press release) "Using advanced nuclear magnetic resonance spectroscopy, we were able to provide an unprecedented view of the internal structure of the protein clumps that form in the disease, which we hope will one day lead to new therapies." The gene associated with ... and more » Structure of brain plaques in Huntington's disease described by Pitt team University of Pittsburgh Schools of the ... - EurekAlert (press...	nmrlearner	Online News	0	02-03-2016 10:22 PM
Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com <img alt="" height="1" width="1"> Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... Nature.com Volumes of the hippocampi and entorhinal cortices in the ANM cohort were obtained using FreeSurfer 5.1.0 (freely available from http://surfer.nmr.mgh.harvard.edu/) from 276 ANM subjects who had undergone structural MRI. These regions were selected as ... Read here	nmrlearner	Online News	0	06-17-2015 08:01 AM
[NMR paper] 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ?-viniferin glucoside: implications in Alzheimer's disease. 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ?-viniferin glucoside: implications in Alzheimer's disease. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol ?-viniferin glucoside: implications in Alzheimer's disease. Biochim Biophys Acta. 2013 Nov;1830(11):5068-74 Authors: Richard T, Papastamoulis Y, Waffo-Teguo P, Monti JP ...	nmrlearner	Journal club	0	03-22-2014 04:03 PM
Protein structures give disease clues - EurekAlert (press release) <img alt="" height="1" width="1" /> Protein structures give disease clues EurekAlert (press release) Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat ... and more » Protein structures give disease clues - EurekAlert (press release) More...	nmrlearner	Online News	0	02-01-2012 09:28 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off