New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein

		BioNMR > NMR community > Online News
New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein \| Scientific Reports - Nature.com

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

08-09-2022, 01:50 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein | Scientific Reports - Nature.com

New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein | Scientific Reports - Nature.com

New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein | Scientific Reports Nature.com Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Role of a bacterial glycolipid in Sec-independent membrane protein insertion \| Scientific Reports - Nature.com Role of a bacterial glycolipid in Sec-independent membrane protein insertion \| Scientific Reports - Nature.com Role of a bacterial glycolipid in Sec-independent membrane protein insertion \| Scientific Reports Nature.com Read here	nmrlearner	Online News	0	07-18-2022 03:28 PM
[ASAP] Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors https://pubs.acs.org/cms/10.1021/acs.biochem.2c00223/asset/images/medium/bi2c00223_0002.gif Biochemistry DOI: 10.1021/acs.biochem.2c00223 More...	nmrlearner	Journal club	0	06-17-2022 08:24 AM
Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants \| Scientific Reports - Nature.com Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants \| Scientific Reports - Nature.com Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants \| Scientific Reports Nature.com Read here	nmrlearner	Online News	0	05-21-2022 08:04 PM
A database of calculated solution parameters for the AlphaFold predicted protein structures \| Scientific Reports - Nature.com A database of calculated solution parameters for the AlphaFold predicted protein structures \| Scientific Reports - Nature.com A database of calculated solution parameters for the AlphaFold predicted protein structures \| Scientific Reports Nature.com Read here	nmrlearner	Online News	0	05-05-2022 11:49 PM
Random sampling of the Protein Data Bank: RaSPDB \| Scientific Reports - Nature.com Random sampling of the Protein Data Bank: RaSPDB \| Scientific Reports - Nature.com Random sampling of the Protein Data Bank: RaSPDB \| Scientific Reports Nature.com Read here	nmrlearner	Online News	0	12-18-2021 07:26 AM
Proteinâ??protein interaction inhibitor tackles drug resistance - Nature.com Proteinâ??protein interaction inhibitor tackles drug resistance - Nature.com http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcRJ1m0HrLxCJOVezkUwdp6bTbUk8qIf1ZXpjDbBKz9C9UvAZb_uCsCdDef4-1soEeLC0rNV-OM Nature.com <img alt="" height="1" width="1"> Proteinâ??protein interaction inhibitor tackles drug resistance Nature.com NMR spectroscopy was then used to determine the mechanism of action of the most potent compound, termed iKIX1. The high-resolution structure showed that iKIX1 binds to the three-helix hydrophobic groove of the KIX domain of Gal11A, engaging the same ...	nmrlearner	Online News	0	04-01-2016 09:13 AM
Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor From The DNP-NMR Blog: Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor Keshari, K.R., et al., Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate, 2015. 75(14): p. 1601-9. http://www.ncbi.nlm.nih.gov/pubmed/26177608	nmrlearner	News from NMR blogs	0	10-09-2015 04:49 PM
[NMR900 blog] NMR paper in Nature Scientific Reports NMR paper in Nature Scientific Reports C.E. Norris, S.A. Quideau, S.M. Landhäusser, G.M. Bernard and R.E. Wasylishen, "Tracking Stable Isotope Enrichment in Tree Seedlings with Solid-State NMR Spectroscopy," Nature Scientific Reports 2 (2012) 719. http://dx.doi.org/10.1038/srep00719https://blogger.googleusercontent.com/tracker/8663203727601106205-993472665316978490?l=nmr900.blogspot.com Read complete story on NMR900 blog	nmrlearner	News from NMR blogs	0	10-17-2012 12:14 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off