New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today

		BioNMR > NMR community > Online News
New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

10-13-2015, 06:03 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,733

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today

New Alzheimer's treatments may arise from modeling 'heat shock proteins' - Medical News Today

Medical News Today

New Alzheimer's treatments may arise from modeling 'heat shock proteins'
Medical News Today
Using solid-state nuclear magnetic resonance (NMR) spectroscopy, the researchers identified the exact sites in the alpha-B-crystallin structure that attach to the beta-amyloid. The achievement is the result of painstaking work because of the challenges ...
New field of application for versatile helperPhys.Org
Small heat shock protein as model for Alzheimer's medicationNews-Medical.net

all 5 news articles »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Small heat shock protein as model for Alzheimer's medication - News-Medical.net Small heat shock protein as model for Alzheimer's medication - News-Medical.net http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSs_jrKR5ICaGu4iH3hpUBJnSF5w-iMfF0Qy_VGXVCtMo1BC7oe7a7d_oQiN2r1yXeRz2_shIs News-Medical.net <img alt="" height="1" width="1"> Small heat shock protein as model for Alzheimer's medication News-Medical.net Using a refined procedure of solid-state nuclear magnetic resonance spectroscopy (solid-state NMR), they managed, for the first time ever, to identify the sites in the alpha-B-crystallin that attach to the beta-amyloid. It is the first direct...	nmrlearner	Online News	0	10-13-2015 05:51 AM
Small molecule 'could treat paralysis by triggering nerve repair' - Medical News Today http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcSc1ThQWactvqBySwVLfSER7i03wvjKS50O-SnIKWqb7dBmCSZjkecy4CIK8Yu0OCB6EeurVDw Medical News Today <img alt="" height="1" width="1" /> Small molecule 'could treat paralysis by triggering nerve repair' Medical News Today Using nuclear magnetic resonance (NMR) technology, the team was able to closely analyze the configurations of the two p75 proteins. By introducing the p45 protein - which promotes nerve regeneration - they found it could break up the pairing of the p75 ... Salk scientists uncover new clues to repairing an injured spinal...	nmrlearner	Online News	0	08-06-2014 08:39 PM
How does the 'kissing disease' replicate itself? - Medical News Today <img alt="" height="1" width="1" /> How does the 'kissing disease' replicate itself? Medical News Today To investigate further, he and his team used innovative nuclear magnetic resonance (NMR) techniques to study how the EBNA2 protein of EBV binds to a protein of the TFIIH complex, which helps regulate a protein called RNA polymerase II. RNA polymerase ... and more » How does the 'kissing disease' replicate itself? - Medical News Today More...	nmrlearner	Online News	0	04-11-2014 02:51 PM
HIV Shell Structure Cracked With Help Of Supercomputer - Medical News Today http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcTAodTWvMW0Dy_p5VKZoiAxpB-zn3gOPriLgKpuLdze9QKgva8k0r1ZrR2Un6XiA8Kq4YyLKnU U.S. News & World Report <img alt="" height="1" width="1" /> HIV Shell Structure Cracked With Help Of Supercomputer Medical News Today To try and see the atomic-level detail of the shell, made of over 1,300 identical proteins, researchers have used a range of sophisticated lab tools, from nuclear magnetic resonance spectroscopy and X-ray crystallography, to cryo-electron microscopy ... Supercomputer Helps Build HIV Capsid StructureBioscience Technology...	nmrlearner	Online News	0	05-30-2013 09:46 PM
Scientists Determine 1000 Protein Structures Of Deadly Diseases - Medical News Today <img alt="" height="1" width="1" /> Scientists Determine 1000 Protein Structures Of Deadly Diseases Medical News Today Working together, two scientific organizations have achieved a key milestone earlier than planned: using X-ray crystallography and nuclear magnetic resonance to probe at the atomic level, they have determined the structure of 1000 proteins from more ... Scientists Determine 1000 Protein Structures Of Deadly Diseases - Medical News Today More...	nmrlearner	Online News	0	06-12-2012 10:36 AM
E. coli Enzyme Must Move To Function: Findings Could Lead To Novel Approaches ... - Medical News Today (press release) <img alt="" height="1" width="1" /> E. coli Enzyme Must Move To Function: Findings Could Lead To Novel Approaches ... Medical News Today (press release) For the new study, the scientists turned to an imaging technique known as nuclear magnetic resonance (NMR) spectroscopy, in combination with X-ray crystallography. Unlike X-ray crystallography, a technique used to determine the structure of proteins in ... E. coli Enzyme Must Move To Function: Findings Could Lead To Novel Approaches ... - Medical News Today (press release) More...	nmrlearner	Online News	0	04-08-2011 11:42 AM
Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis - Medical News Today (press release) <img alt="" height="1" width="1" /> Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis Medical News Today (press release) "Our new NG Class Detergents give biologists enhanced tools to solve the structure of membrane proteins using advanced techniques, such as nuclear magnetic resonance and X-ray diffraction." Membrane proteins are important because they mediate the ... and more » Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis - Medical News Today (press release) More...	nmrlearner	Online News	0	02-17-2011 09:41 AM
[NMR paper] Yeast heat shock transcription factor N-terminal activation domains are unstructured Yeast heat shock transcription factor N-terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Yeast heat shock transcription factor N-terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy. Protein Sci. 1996 Feb;5(2):262-9...	nmrlearner	Journal club	0	08-22-2010 02:27 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off