Neutrons paint atomic portrait of prototypical cell signaling enzyme - EurekAlert

		BioNMR > NMR community > Online News
Neutrons paint atomic portrait of prototypical cell signaling enzyme - EurekAlert

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-02-2019, 01:35 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Neutrons paint atomic portrait of prototypical cell signaling enzyme - EurekAlert

Neutrons paint atomic portrait of prototypical cell signaling enzyme EurekAlertDirect observations of the structure and catalytic mechanism of a prototypical kinase enzyme -- protein kinase A or PKA -- will provide researchers and drug ...

Neutrons paint atomic portrait of prototypical cell signaling enzyme - EurekAlert
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Neutrons Paint Atomic Portrait of Protein Kinase A - Technology Networks Neutrons Paint Atomic Portrait of Protein Kinase A Technology NetworksDirect observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug ... Neutrons Paint Atomic Portrait of Protein Kinase A - Technology Networks More...	nmrlearner	Online News	0	03-25-2019 08:37 PM
Enzyme's movement may be key to new cancer drugs - EurekAlert (press release) http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcTsNtH9YpxxAQ6ksPtPSZU0Z09vvbZhDQEOKHaJ3v7FZ4YWTEIyvhvW3H5toO9Rh1H0x8fgcCvA EurekAlert (press release) <img alt="" height="1" width="1"> Enzyme's movement may be key to new cancer drugs EurekAlert (press release) To watch a kinase called mitogen-activated protein kinase (MAPK) p38 in action, the researchers used nuclear magnetic resonance (NMR) spectroscopy. All necessary molecules had to bind to p38 for the enzyme to become active. Only then could the ... Enzyme's movement may be key to new cancer drugs - EurekAlert (press...	nmrlearner	Online News	0	05-15-2018 03:38 PM
Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release) Research reveals atomic-level changes in ALS-linked protein - EurekAlert (press release) http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcThs4eeexkdVGsFide9UyDrq0uU25P0SvZzPawjlV9QsOaZJyx5o5GDb89JIp6O2B8ublj1dx8q EurekAlert (press release) <img alt="" height="1" width="1"> Research reveals atomic-level changes in ALS-linked protein EurekAlert (press release) The protein collects in membrane-less organelles, where it may use its low-complexity domain to stick together, much in the way that water collects into droplets on the outside of a cold soda bottle on a humid summer day....	nmrlearner	Online News	0	01-19-2018 03:47 AM
Atomic-level motion may drive bacteria's ability to evade immune system defenses Indiana University - EurekAlert (press release) http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcQua6i8f-w_dssq0DquUvqjy5IzgyN86xgfQGTv4zVJsgdI861V1sPT9EQddr7PiQtfcf1GCC-3 EurekAlert (press release) <img alt="" height="1" width="1"> Atomic-level motion may drive bacteria's ability to evade immune system defenses Indiana University EurekAlert (press release) Through the use of nuclear magnetic resonance spectroscopy, he and colleagues measured the movement of atoms in CzrA and identified those most affected by zinc. They then "swapped" these atoms out with different amino acids and found that the protein ... and more »...	nmrlearner	Online News	0	04-21-2017 03:35 PM
Alzheimer fibrils at atomic resolution - EurekAlert (press release) <img alt="" height="1" width="1"> Alzheimer fibrils at atomic resolution EurekAlert (press release) Only solid-state nuclear magnetic resonance spectroscopy (solid-state NMR) is capable of offering a view at the atomic level in this case. New developments in methods made it possible to measure a network of distances between the atoms in the protein ... and more » Alzheimer fibrils at atomic resolution - EurekAlert (press release) More...	nmrlearner	Online News	0	08-06-2016 07:22 PM
Cell signaling, post-translational protein modifications and NMR spectroscopy Cell signaling, post-translational protein modifications and NMR spectroscopy Abstract Post-translationally modified proteins make up the majority of the proteome and establish, to a large part, the impressive level of functional diversity in higher, multi-cellular organisms. Most eukaryotic post-translational protein modifications (PTMs) denote reversible, covalent additions of small chemical entities such as phosphate-, acyl-, alkyl- and glycosyl-groups onto selected subsets of modifiable amino acids. In turn, these modifications induce highly specific changes in the chemical ...	nmrlearner	Journal club	0	09-29-2012 11:56 AM
Scripps Research scientists find E. coli enzyme must move to function - EurekAlert (press release) <img alt="" height="1" width="1" /> Scripps Research scientists find E. coli enzyme must move to function EurekAlert (press release) For the new study, the scientists turned to an imaging technique known as nuclear magnetic resonance (NMR) spectroscopy, in combination with X-ray crystallography. Unlike X-ray crystallography, a technique used to determine the structure of proteins in ... and more » Scripps Research scientists find E. coli enzyme must move to function - EurekAlert (press release) More...	nmrlearner	Online News	0	04-07-2011 11:40 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off