[NMR paper] Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation
Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation
B-cell lymphoma 2 (Bcl-2) proteins are the main regulators of mitochondrial apoptosis. Anti-apoptotic Bcl-2 proteins possess a hydrophobic tail-anchor enabling them to translocate to their target membrane and to shift into an active conformation where they inhibit pro-apoptotic Bcl-2 proteins to ensure cell survival. To address the unknown molecular basis of their cell-protecting functionality, we used intact human Bcl-2 protein natively residing at the mitochondrial...
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04-28-2021 10:16 PM
[NMR paper] NMR structure of a full-length single-pass membrane protein NRADD.
NMR structure of a full-length single-pass membrane protein NRADD.
Related Articles NMR structure of a full-length single-pass membrane protein NRADD.
Proteins. 2019 Apr 29;:
Authors: Nadezhdin KD, Goncharuk SA, Arseniev AS, Mineev KS
Abstract
Structural study of any single-pass membrane protein is both an important and challenging task. In this report, we present the structure of a neurotrophin receptor-alike death-domain protein, NRADD. The structure and dynamics of the protein was investigated by conventional nuclear magnetic...
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04-30-2019 03:58 PM
A Novel Domain Assembly Routine for Creating Full-Length Models of Membrane Proteins from Known Domain Structures
A Novel Domain Assembly Routine for Creating Full-Length Models of Membrane Proteins from Known Domain Structures
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00995/20171211/images/medium/bi-2017-00995a_0005.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00995
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/IYVe61xDFY0
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12-12-2017 02:12 AM
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and ... - Nature.com
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and ... - Nature.com
<img alt="" height="1" width="1">
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and ...
Nature.com
DISC1 protein pathology and its interaction with dopamine homeostasis is a novel cellular mechanism that is relevant for behavioral control and may have a role in mental illness. ..... (d) NMR analysis of ventricle size. The tgDISC1 rat (n=8) had a ...
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01-20-2016 11:54 PM
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to ... - Nature.com
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to ... - Nature.com
<img alt="" height="1" width="1">
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to ...
Nature.com
DISC1 protein pathology and its interaction with dopamine homeostasis is a novel cellular mechanism that is relevant for behavioral control and may have a role in mental illness. ..... (d) NMR analysis of ventricle size. The tgDISC1 rat (n=8) had a ...
Read here
nmrlearner
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01-12-2016 04:01 PM
[NMR paper] Dynamic Interaction Between Membrane-Bound Full-Length Cytochrome P450 and Cytochrome b5 Observed by Solid-State NMR Spectroscopy.
Dynamic Interaction Between Membrane-Bound Full-Length Cytochrome P450 and Cytochrome b5 Observed by Solid-State NMR Spectroscopy.
Dynamic Interaction Between Membrane-Bound Full-Length Cytochrome P450 and Cytochrome b5 Observed by Solid-State NMR Spectroscopy.
Sci Rep. 2013 Aug 29;3:2538
Authors: Yamamoto K, Dürr UH, Xu J, Im SC, Waskell L, Ramamoorthy A
Abstract
Microsomal monoxygenase enzymes of the cytochrome-P450 family are found in all biological kingdoms, and play a central role in the breakdown of metabolic as well as...
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08-30-2013 04:35 PM
NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment
NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment
Abstract Targeting the receptor for the advanced glycation endproducts (RAGE) signalling has a potential for the prevention and treatment of several pathologies. Extracellular activation of RAGE triggers the interactions of the RAGE cytoplasmic tail with intracellular protein partners. Here the cytoplasmic tail of RAGE has been investigated by NMR as part of the full-length protein, in the presence of a membrane-mimicking environment. The isolated cytoplasmic tail has also been studied...
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09-24-2012 01:02 AM
[NMR paper] Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepar
Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis.
Related Articles Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis.
J Am Chem Soc. 2004 Mar 3;126(8):2439-46
Authors: Kochendoerfer GG, Jones DH, Lee S, Oblatt-Montal M, Opella SJ, Montal M
Vpu is an 81-residue integral membrane protein encoded in the HIV-1 genome that is of considerable interest because it plays important roles in the release of virus particles...
Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and ... - Nature.com
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