NCI to Offer $1.4M for Research Into Low-Abundance Small-Molecule Cancer ... - GenomeWeb

		BioNMR > NMR community > Online News
NCI to Offer $1.4M for Research Into Low-Abundance Small-Molecule Cancer ... - GenomeWeb

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

01-11-2015, 09:05 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

NCI to Offer $1.4M for Research Into Low-Abundance Small-Molecule Cancer ... - GenomeWeb

NCI to Offer $1.4M for Research Into Low-Abundance Small-Molecule Cancer ...
GenomeWeb
NCI's goal for the research, which should focus on brain, lung, and breast cancers, is to develop â??new tools and methodologies for the detection, isolation and characterization of proteins, peptides, or micro RNAsâ?? that generally occur at concentration ...

NCI to Offer $1.4M for Research Into Low-Abundance Small-Molecule Cancer ... - GenomeWeb
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
[NMR paper] Screening protein-small molecule interactions by NMR. Screening protein-small molecule interactions by NMR. Related Articles Screening protein-small molecule interactions by NMR. Methods Mol Biol. 2013;1008:389-413 Authors: Davis B Abstract Nuclear magnetic resonance (NMR) is well suited to probing the interactions between ligands and macromolecular receptors. It is a truly label-free technique, requiring only the presence of atoms (usually (1)H or (19)F) which give rise to observable resonances on either the ligand or the receptor. A number of parameters associated with these resonances can...	nmrlearner	Journal club	0	06-05-2013 06:53 PM
Small-Molecule Binding Sites on Proteins Establishedby Paramagnetic NMR Spectroscopy Small-Molecule Binding Sites on Proteins Establishedby Paramagnetic NMR Spectroscopy Jia-Ying Guan, Peter H. J. Keizers, Wei-Min Liu, Frank Lo?hr, Simon P. Skinner, Edwin A. Heeneman, Harald Schwalbe, Marcellus Ubbink and Gregg Siegal http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja401323m/aop/images/medium/ja-2013-01323m_0009.gif Journal of the American Chemical Society DOI: 10.1021/ja401323m http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/jacsat/~4/ZukfjIRmQq8	nmrlearner	Journal club	0	04-05-2013 11:03 PM
[NMR paper] NMR Methods for Detection of Small Molecule Binding to RGS4. NMR Methods for Detection of Small Molecule Binding to RGS4. Related Articles NMR Methods for Detection of Small Molecule Binding to RGS4. Methods Enzymol. 2013;522:133-52 Authors: Storaska AJ, Neubig RR Abstract The duration and amplitude of G-protein-coupled receptor (GPCR) signaling is controlled by regulator of G-protein signaling (RGS) proteins. The 20 RGS family members act as GTPase accelerating proteins through their interaction with the G? subunit of the G??? heterotrimer. Their influence over GPCR signaling has attracted many to...	nmrlearner	Journal club	0	02-05-2013 09:51 PM
Agilent Awards Harvard Researcher $373K for Protein Research Using NMR - GenomeWeb Daily News Agilent Awards Harvard Researcher $373K for Protein Research Using NMR - GenomeWeb Daily News <img alt="" height="1" width="1" /> Agilent Awards Harvard Researcher $373K for Protein Research Using NMR GenomeWeb Daily News The Agilent Thought Leader Award will support Gerhard and his laboratory's research developing fast and efficient assignment methods for large proteins using high magnetic field NMR spectroscopy, and then making them accessible to the structural ... TRADE NEWS: Agilent Technologies Supports Harvard Medical School Professor's ...MarketWatch (press release) all 15...	nmrlearner	Online News	0	09-14-2011 09:34 PM
[CNS Yahoo group] How to add bond between protein residue and a small molecule in CNS How to add bond between protein residue and a small molecule in CNS Dear All, I'm stuck in a step where in i need to connect a bond an amino acid residue and a small molecule in CNS Thank you. Joseph More...	nmrlearner	News from other NMR forums	0	08-07-2011 01:35 AM
[NMR paper] NMR structure of a complex between MDM2 and a small molecule inhibitor. NMR structure of a complex between MDM2 and a small molecule inhibitor. Related Articles NMR structure of a complex between MDM2 and a small molecule inhibitor. J Biomol NMR. 2004 Oct;30(2):163-73 Authors: Fry DC, Emerson SD, Palme S, Vu BT, Liu CM, Podlaski F MDM2 is a regulator of cell growth processes that acts by binding to the tumor suppressor protein p53 and ultimately restraining its activity. While inactivation of p53 by mutation is commonly observed in human cancers, a substantial percentage of tumors express wild type p53. In many of...	nmrlearner	Journal club	0	11-24-2010 10:01 PM
Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Scr Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C. Related Articles Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C. J Med Chem. 2010 Nov 12; Authors: Scheich C, Puetter V, Schade M Protein target-based discovery of novel antibiotics has been largely unsuccessful despite rich genome information. Particularly in need are new antibiotics for tuberculosis, which kills 1.6 million people annually and shows a rapid increase in...	nmrlearner	Journal club	0	11-16-2010 04:13 PM
Small Molecule NMR Scientist (B.S./ M.S.) at Novartis Ag (Cambridge, MA) Small Molecule NMR Scientist (B.S./ M.S.) at Novartis Ag (Cambridge, MA) using the state-of-the-art NMR methodologies. As an NMR scientist within the team, you will be responsible for ... in small molecular NMR with demonstrated success in modern NMR methodologies. Demonstrated skills in data collection... More...	nmrlearner	Job marketplace	0	08-19-2010 02:32 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off