[NMR paper] NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering
The SARS-CoV-2 nucleocapsid (N) protein is crucial for the highly organized packaging and transcription of the genomic RNA. Studying atomic details of the role of its intrinsically disordered regions (IDRs) in RNA recognition is challenging due to the absence of structure and to the repetitive nature of their primary sequence. IDRs are known to act in concert with the folded domains of N and here we use NMR spectroscopy to identify the priming events...
[NMR paper] Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
ACS Med Chem Lett. 2014 Jan 9;5(1):23-28
Authors: Dias DM, Van Molle I, Baud MG, Galdeano C, Geraldes CF, Ciulli A
Abstract
Modulation of protein-protein interactions (PPIs) with small molecules has been hampered by a lack of lucid methods capable of reliably identifying high-quality hits. In fragment screening, the low ligand efficiencies associated with...
Investigating the druggability of SARS-CoV-2 nucleocapsid protein RNA interactions - Phys.org
Linear Mode
