Identification of novel nanobodies to specifically target SARS-CoV-2 replication protein - News-Medical.Net

		BioNMR > NMR community > Online News
Identification of novel nanobodies to specifically target SARS-CoV-2 replication protein - News-Medical.Net

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

11-01-2021, 07:07 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Identification of novel nanobodies to specifically target SARS-CoV-2 replication protein - News-Medical.Net

Identification of novel nanobodies to specifically target SARS-CoV-2 replication protein - News-Medical.Net

Identification of novel nanobodies to specifically target SARS-CoV-2 replication protein News-Medical.Net Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
[NMR paper] NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19 NMR-Based Analysis of Nanobodies to SARS-CoV-2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID-19 Following the entry into the host cell, SARS-CoV-2 replication is mediated by the replication transcription complex (RTC) assembled through a number of nonstructural proteins (Nsps). A monomeric form of Nsp9 is particularly important for RTC assembly and function. In the present study, 136 unique nanobodies targeting Nsp9 are generated. Several nanobodies belonging to different B-cell lineages are expressed, purified, and characterized. Results from immunoassays applied to purified...	nmrlearner	Journal club	0	10-28-2021 09:25 PM
Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1 - News-Medical.Net Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1 - News-Medical.Net Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1 News-Medical.Net Read here	nmrlearner	Online News	0	08-02-2021 05:20 PM
Researchers probe intriguing interaction between sugars and the SARS-CoV-2 spike protein - News-Medical.Net Researchers probe intriguing interaction between sugars and the SARS-CoV-2 spike protein - News-Medical.Net Researchers probe intriguing interaction between sugars and the SARS-CoV-2 spike protein News-Medical.Net Read here	nmrlearner	Online News	0	04-17-2021 01:47 AM
ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain - DocWire News ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain - DocWire News ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain DocWire News Read here	nmrlearner	Online News	0	01-22-2021 11:39 PM
Mass production of SARS-CoV-2 ORF8 protein using a chemical-inducible system in tobacco BY-2 cells - News-Medical.Net Mass production of SARS-CoV-2 ORF8 protein using a chemical-inducible system in tobacco BY-2 cells - News-Medical.Net Mass production of SARS-CoV-2 ORF8 protein using a chemical-inducible system in tobacco BY-2 cells News-Medical.Net Read here	nmrlearner	Online News	0	10-09-2020 08:31 PM
Scientists refine SARS-CoV-2 protein structures - News-Medical.Net Scientists refine SARS-CoV-2 protein structures News-Medical.Net Scientists refine SARS-CoV-2 protein structures - News-Medical.Net More...	nmrlearner	Online News	0	10-09-2020 08:31 PM
Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach Abstract The insertase BamA is an essential protein of the bacterial outer membrane. Its 16-stranded transmembrane Î²-barrel contains a lateral gate as a key functional element. This gate is formed by the C-terminal half of the last Î²-strand. The BamA barrel was previously found to sample different conformations in aqueous solution, as well as different gate-open, gate-closed, and collapsed conformations in...	nmrlearner	Journal club	0	05-09-2019 05:55 AM
Study reveals molecular function of protein essential for replication of H5N1 ... - News-Medical.net Study reveals molecular function of protein essential for replication of H5N1 ... - News-Medical.net http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcQqQVkN2sOlkhvYowf7yXaO0RlhCYQZ_9zOSx7m7tG2kLZe9aCik1IvkvJcZVU-_BYhJS__lMZX News-Medical.net <img alt="" height="1" width="1"> Study reveals molecular function of protein essential for replication of H5N1 ... News-Medical.net An international collaboration of scientists from the CEA, CNRS, University Joseph Fourier, the EMBL and the ILL has revealed the molecular function of a protein essential for replication of H5N1 influenza...	nmrlearner	Online News	0	12-10-2015 05:49 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off