How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review

		BioNMR > NMR community > Online News
How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

02-29-2020, 09:52 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review

How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review

How can NMR spectroscopy help protein biopharmaceutical development? European Pharmaceutical Review Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Selective suppression of excipient signals in 2D 1 Hâ?? 13 C methyl spectra of biopharmaceutical products Selective suppression of excipient signals in 2D 1 Hâ?? 13 C methyl spectra of biopharmaceutical products Abstract While the use of 1Hâ??13C methyl correlated NMR spectroscopy at natural isotopic abundance has been demonstrated as feasible on protein therapeutics as large as monoclonal antibodies, spectral interference from aliphatic excipients remains a significant obstacle to its widespread application. These signals can cause large baseline artifacts, obscure protein resonances, and cause dynamic range suppression of weak peaks in non-uniform...	nmrlearner	Journal club	0	01-07-2019 05:49 AM
Quality assessment of biologics: higher order structure analysis using NMR - European Pharmaceutical Review Quality assessment of biologics: higher order structure analysis using NMR European Pharmaceutical ReviewThe webinar will describe how 2D NMR can offer protein biochemists unprecedented analytical precision. By assigning just one spectrum, users can obtain a ... Quality assessment of biologics: higher order structure analysis using NMR - European Pharmaceutical Review More...	nmrlearner	Online News	0	01-07-2019 05:49 AM
[NMR paper] What NMR can do in the biopharmaceutical industry. What NMR can do in the biopharmaceutical industry. Related Articles What NMR can do in the biopharmaceutical industry. J Pharm Biomed Anal. 2017 Jul 08;: Authors: Kiss R, Fizil Á, Szántay C Abstract Nuclear magnetic resonance (NMR) spectroscopy has a unique capability to probe the primary and higher order molecular structure and the structural dynamics of biomolecules at an atomic resolution, and this capability has been greatly fortified over the last five decades by an astonishing NMR instrumental and methodological...	nmrlearner	Journal club	0	08-02-2017 02:19 PM
[NMR paper] Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS. J Pharm Biomed Anal. 2017 Feb 20;135:126-132 Authors: Bednarek E, Sitkowski J, Bocian W, Borowicz P, P?ucienniczak G, Stadnik D, Surmacz-Chwedoruk W,...	nmrlearner	Journal club	0	05-26-2017 08:36 PM
CIL, Nexomics Biosciences enter supply agreement to offer isotope-labeled ... - Pharmaceutical Business Review <img alt="" height="1" width="1" /> CIL, Nexomics Biosciences enter supply agreement to offer isotope-labeled ... Pharmaceutical Business Review Cambridge Isotope Laboratories CEO Joel Bradley said Nexomics' success in developing techniques to determine protein structure using Nuclear Magnetic Resonance (NMR) spectroscopy nicely complements the company's mission to offer isotope enriched ... CIL, Nexomics Biosciences enter supply agreement to offer isotope-labeled ... - Pharmaceutical Business Review More...	nmrlearner	Online News	0	01-29-2014 02:01 PM
The Importance of Characterization in Biosimilars Development - Pharmaceutical Technology Magazine <img alt="" height="1" width="1" /> The Importance of Characterization in Biosimilars Development Pharmaceutical Technology Magazine Depending on the molecule, non-routine techniques such as protein nuclear magnetic resonance (NMR) and x-ray crystallography may also be utilized. In fact, a whole panel of methods should be employed, including orthogonal techniques to analyze ... The Importance of Characterization in Biosimilars Development - Pharmaceutical Technology Magazine More...	nmrlearner	Online News	0	09-21-2013 02:52 AM
Quantitative NMR spectroscopy in pharmaceutical applications Quantitative NMR spectroscopy in pharmaceutical applications Publication year: 2010 Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 57, Issue 2</br> Ulrike Holzgrabe</br> </br> </br></br>	nmrlearner	Journal club	0	03-09-2012 09:16 AM
Affymetrix launches NG Class detergents for better protein analysis - Pharmaceutical Business Review <img alt="" height="1" width="1" /> Affymetrix launches NG Class detergents for better protein analysis Pharmaceutical Business Review Affymetrix chief commercial officer Andy Last said the new NG Class Detergents give biologists enhanced tools to solve the structure of membrane proteins using advanced techniques, such as nuclear magnetic resonance and X-ray diffraction. ... and more » Affymetrix launches NG Class detergents for better protein analysis - Pharmaceutical Business Review More...	nmrlearner	Online News	0	02-15-2011 09:29 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off