[NMR paper] Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Related Articles Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Biochem Biophys Res Commun. 2014 Feb 10;
Authors: Lindert S, Maslennikov I, Chiu E, Pierce LC, Andrew McCammon J, Choe S
Abstract
About 8,000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate...
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Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits
Publication date: Available online 10 February 2014
Source:Biochemical and Biophysical Research Communications</br>
Author(s): Steffen Lindert , Innokentiy Maslennikov , Ellis Chiu , Levi C Pierce , J. Andrew McCammon , Senyon Choe</br>
About 8,000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate drug discovery and development. The main problem, however,...
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02-10-2014 08:46 PM
[NMR paper] Structure determination of aligned samples of membrane proteins by NMR spectroscopy.
Structure determination of aligned samples of membrane proteins by NMR spectroscopy.
Related Articles Structure determination of aligned samples of membrane proteins by NMR spectroscopy.
Magn Reson Chem. 2004 Feb;42(2):162-71
Authors: Nevzorov AA, Mesleh MF, Opella SJ
The paper briefly reviews the process of determining the structures of membrane proteins by NMR spectroscopy of aligned samples, describes the integration of recent developments in the interpretation of spectra of aligned proteins and illustrates the application of these methods...
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[NMR paper] Structure determination of membrane proteins by NMR spectroscopy.
Structure determination of membrane proteins by NMR spectroscopy.
Related Articles Structure determination of membrane proteins by NMR spectroscopy.
Biochem Cell Biol. 2002;80(5):597-604
Authors: Opella SJ, Nevzorov A, Mesleb MF, Marassi FM
Current strategies for determining the structures of membrane proteins in lipid environments by NMR spectroscopy rely on the anisotropy of nuclear spin interactions, which are experimentally accessible through experiments performed on weakly and completely aligned samples. Importantly, the anisotropy of...
Facile backbone structure determination of human membrane proteins by NMR spectroscopy - Nature.com
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