Beyond slow two-state protein conformational exchange using CEST: applications to three-state protein interconversion on the millisecond timescale
Beyond slow two-state protein conformational exchange using CEST: applications to three-state protein interconversion on the millisecond timescale
Abstract
Although NMR spectroscopy is routinely used to study the conformational dynamics of biomolecules, robust analyses of the data are challenged in cases where exchange is more complex than two-state, such as when a â??visibleâ?? major conformer exchanges with two â??invisibleâ?? minor states on the millisecond timescale. It is becoming increasingly clear that chemical exchange saturation transfer...
Defining a length scale for millisecond-timescale protein conformational exchange | Proceedings of the National ... - pnas.org
Linear Mode
