Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org

		BioNMR > NMR community > Online News
Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

12-01-2015, 11:22 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,733

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org

Early progress reported in designing drugs that target 'disordered' proteins - Phys.Org

Phys.Org

Early progress reported in designing drugs that target 'disordered' proteins
Phys.Org
The p27 protein works by binding to an enzyme and forming a complex that blocks cell division. This type of regulation is necessary to keep cells in check when not otherwise instructed to divide. In this study St. Jude researchers used NMR spectroscopy ...

and more »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Quantum Criticality in life's proteins - Phys.Org Quantum Criticality in life's proteins - Phys.Org http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcQmmwn4be-zSvmVia_TPrZnP9wSO0Vi4PWFRAoab1bWQiR7ZtGMlOjrGOQYnjAJsceK0vyZcMEu Phys.Org <img alt="" height="1" width="1"> Quantum Criticality in life's proteins Phys.Org In particular, they selected NMR spectra from the Protein Data Bank and used a technique known as the extended Huckel Hamiltonion method to calculate HOMO/LUMO orbitals for the proteins. For more comments on HOMO/LUMO orbital calculations you ...	nmrlearner	Online News	0	04-13-2015 09:11 PM
Biomarked for Deathâ??Four Blood Proteins Can Predict Early Demise - Genetic Engineering News (blog) http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcRkoPt5Dyp7KewAE_J97PScBoa491M0a1ZPhGnp9UtY9NNoRJu_mLGBAP1okaqZCF5Ypm9dvF0 Genetic Engineering News (blog) <img alt="" height="1" width="1" /> Biomarked for Deathâ??Four Blood Proteins Can Predict Early Demise Genetic Engineering News (blog) The researchers detailed their results February 25 in PLOS Medicine, in an article entitled â??Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons.â?? To carry ... Biomarked for Deathâ??Four...	nmrlearner	Online News	0	02-28-2014 07:08 PM
Proteins' passing phases revealed - Phys.Org <img alt="" height="1" width="1" /> Proteins' passing phases revealed Phys.Org X-ray crystallography and, more recently, nuclear magnetic resonance spectroscopy are the most common tools to see how the amino acids in a protein chain arrange themselves based on their attractive and repulsive energies, but they say nothing about ... Proteins' passing phases revealed - Phys.Org More...	nmrlearner	Online News	0	12-05-2013 06:57 PM
A trick to fold proteins more quickly - PhysOrg.com - Phys.Org <img alt="" height="1" width="1" /> A trick to fold proteins more quickly - PhysOrg.com Phys.Org "We exploit the experimental data obtained observing the proteins through nuclear magnetic resonance, and use them to create restraints to be applied to the model", explained Laio, who has coordinated the research published in Proceedings of the ... A trick to fold proteins more quickly - PhysOrg.com - Phys.Org More...	nmrlearner	Online News	0	05-08-2013 02:49 PM
[NMR paper] Designing Dipolar Recoupling and Decoupling Experiments for Biological Solid-State NMR Using Interleaved Continuous Wave and rf Pulse Irradiation. Designing Dipolar Recoupling and Decoupling Experiments for Biological Solid-State NMR Using Interleaved Continuous Wave and rf Pulse Irradiation. Designing Dipolar Recoupling and Decoupling Experiments for Biological Solid-State NMR Using Interleaved Continuous Wave and rf Pulse Irradiation. Acc Chem Res. 2013 Apr 4; Authors: Bjerring M, Jain S, Paaske B, Vinther JM, Nielsen NC Abstract Rapid developments in solid-state NMR methodologyhave boosted this technique into a highly versatile tool for structural biology. The invention of...	nmrlearner	Journal club	0	04-06-2013 11:18 AM
Intrinsically disordered proteins: A conversation with Rohit Pappu - Phys.Org Intrinsically disordered proteins: A conversation with Rohit Pappu - Phys.Org <img alt="" height="1" width="1" /> Intrinsically disordered proteins: A conversation with Rohit Pappu Phys.Org The earliest clue was that some protein segments didn't show up in X-ray crystallography or NMR studies, the standard ways of studying protein structure. By the 1990s people who studied how proteins interact with DNA had noticed the proteins often ... and more » Read here	nmrlearner	Online News	0	09-20-2012 06:36 PM
[NMR tweet] [ebook] Progress in Nuclear Magnetic Spectroscopy Volume 1 Issue 1: Progress in Nucle Progress in Nuclear Magnetic Spectroscopy Volume 1 Issue 1: Progress in Nuclear Magnetic Resonance Spect... http://bit.ly/do1tRf Published by ebook30 (EBOOK30.com) on 2010-11-22T04:38:13Z Source: Twitter	nmrlearner	Twitter NMR	0	11-22-2010 05:39 AM
[NMR tweet] [science] Progress in Nuclear Magnetic Spectroscopy Volume 1 Issue 1: Progress in Nuc Progress in Nuclear Magnetic Spectroscopy Volume 1 Issue 1: Progress in Nuclear Magnetic Resonance Spe... http://bit.ly/do1tRf Published by ebook30 (EBOOK30.com) on 2010-11-22T04:29:55Z Source: Twitter	nmrlearner	Twitter NMR	0	11-22-2010 04:33 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off